Results 251 to 260 of about 639,600 (311)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Predictors of deep brain stimulation response in patients with obsessive compulsive disorder: a systematic review and meta-analysis. [PDF]

Sci Rep
Thavarajasingam SG, Vishnu K S, Divanbeighi Zand AP, Ramsay DSC, Salih A, Baby MV, Thakker RD, Nagi J, Eraifej J, Amirthalingam G, Shaked Z, Sivov H, Jankovic D, Kramer A, Linsmayer D, Nowacki A, Groppa S, Glaser MB, Hinnerk-Mehrkens J, Ringel F, Green AL.   +20 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Clinical outcomes and anti-inflammatory mechanisms of nucleus basalis of Meynert deep brain stimulation in Alzheimer's disease. [PDF]

Front Neurol
Chen Y, Du T, Lian T, Jiang Y, Yuan T, Li J, Meng F, Yang A, Zhang W, Zhang J.   +9 more
europepmc   +1 more source

Cellular and Molecular Mechanisms of Neuroprotection in Deep Brain Stimulation for Parkinson's Disease. [PDF]

Biomedicines
Nag A, Shah S, Lucke-Wold B.
europepmc   +1 more source

Real-Time ECG Artifact Removal for Adaptive Deep Brain Stimulation: A Comparative Study. [PDF]

Sensors (Basel)
Silvi L, D'Onofrio V, Cauzzo S, Antonini A, Guerra A, Porcaro C.   +5 more
europepmc   +1 more source

Non-Invasive Brain Stimulation in Frontotemporal Dementia: A Systematic Review of Non-Pharmacological Treatment Approaches. [PDF]

Int J Mol Sci
Dognini E, Cerino A, Manenti R, Cotelli M, Borroni B.   +4 more
europepmc   +1 more source

Advances in deep brain stimulation for movement disorders. [PDF]

Ann Med Surg (Lond)
Zaib M, Khizar M, Ali Q, Mahato RK.
europepmc   +1 more source

Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer's Disease-A Systematic Review. [PDF]

Brain Sci
Valverde HP, Clark BJ, Hogeveen J, Clark VP.   +3 more
europepmc   +1 more source