Results 61 to 70 of about 4,226 (251)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

An Enhanced Brain Storm Sine Cosine Algorithm for Global Optimization Problems

IEEE Access, 2019
The conventional sine cosine algorithm (SCA) does not appropriately balance exploration and exploitation, causing premature convergence, especially for complex optimization problems, such as the complex shifted or shifted rotated problems.
Chunquan Li, Zu Luo, Zhenshou Song, Feng Yang, Jinghui Fan, Peter X. Liu   +5 more
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Hybrid Improved Brain Storm Optimization with Support Vector Machine for Cardiovascular Diseases Classification

Tsinghua Science and Technology
Most existing classification algorithms for cardiovascular disease are limited to specific diseases and cannot categorize the severity of the diseases. These algorithms still need to be improved in terms of accuracy and generalizability.
Yifei Sun, Wenya Shi, Shi Cheng, Kashif Talpur, Yuhui Shi   +4 more
doaj   +1 more source

A Hybrid Swarm Intelligence Algorithm for Vehicle Routing Problem With Time Windows

IEEE Access, 2020
The Vehicle Routing Problem with Time Windows (VRPTW) has drawn considerable attention in the last decades. The objective of VRPTW is to find the optimal set of routes for a fleet of vehicles in order to serve a given set of customers within capacity and
Yang Shen, Mingde Liu, Jian Yang, Yuhui Shi, Martin Middendorf   +4 more
doaj   +1 more source

Recent Advances in High‐Entropy Nanozymes: From Fabrication to Applications

Advanced Science, EarlyView.
To highlight key achievements and clarify the current landscape of high‐entropy nanozymes (HEAzymes), this review summarizes state‐of‐the‐art developments ranging from thermodynamically and kinetically controlled synthetic strategies; enzyme‐like catalytic types, catalytic characteristics, and underlying mechanisms; to their antioxidative, therapeutic,
Yongjian Ai, Weibo Zhang, Pengjie Wang, Wentao Xu, Huiyuan Guo, Hong‐bin Sun, Meng‐Qi He, Fazheng Ren, Qionglin Liang   +8 more
wiley   +1 more source

ASBSO: An Improved Brain Storm Optimization With Flexible Search Length and Memory-Based Selection

IEEE Access, 2018
Brain storm optimization (BSO) is a newly proposed population-based optimization algorithm, which uses a logarithmic sigmoid transfer function to adjust its search range during the convergent process. However, this adjustment only varies with the current
Yang Yu, Shangce Gao, Yirui Wang, Jiujun Cheng, Yuki Todo   +4 more
doaj   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Steps Toward Vitrification and Banking of Coral Larvae Using Field‐Friendly Cryomesh Technology

Advanced Science, EarlyView.
Cryomesh enables a low‐tech cryopreservation method, adding a valuable option to the coral reef conservation toolkit. The approach reveals how size, toxicity, and developmental stage govern larval survival, while modeling links cooling and rewarming rates to a theoretical upper volume limit.
E. Michael Henley, Jonathan Daly, Claire Lager, Nikolas Zuchowicz, Riley Perry, Jaylyn Oka, Mariko Quinn, Zongqi Guo, Maria Victoria Grosso‐Becerra, Frania Valdez Felix, Anastazia T. Banaszak, Christian R.A. Lippens, Kristen L. Marhaver, Emily Jane Williams, Keri O'Neil, Mary Hagedorn   +15 more
wiley   +1 more source