Results 31 to 40 of about 136 (122)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

BGFS: Design and Development of Brain Genetic Fuzzy System for Data Classification

Journal of Intelligent Systems, 2018
Recently, classification systems have received significant attention among researchers due to the important characteristics and behaviors of analysis required in real-time databases.
Ravi Chandrasekar, Khare Neelu
doaj   +1 more source

A Fault Diagnosis Method of Rolling Bearings Based on Parameter Optimization and Adaptive Generalized S-Transform

Machines, 2022
As for the fault diagnosis of rolling bearings under strong background noises, whether the fault feature extraction is comprehensive and accurate is critical, especially for the data-driven fault diagnosis methods.
Yuwei Peng, Xianghua Ma
doaj   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

A Hybrid BSO-ACO for Dynamic Vehicle Routing Problem on Real-World Road Networks

IEEE Access, 2022
The Dynamic Vehicle Routing Problem With Time Windows (DVRPTW) is an NP-hard problem, which has attracted a lot of attention in the past decades due to its many practical applications in logistics.
Mingde Liu, Qi Song, Qi Zhao, Ling Li, Zhiming Yang, Yingbin Zhang   +5 more
doaj   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

An Improved Brain Storm Optimization with Dynamic Clustering Strategy

MATEC Web of Conferences, 2017
Intelligence algorithms play an increasingly important role in the field of intelligent control. Brain storm optimization (BSO) is a new kind of swarm intelligence algorithm inspired by emulating the collective behavior of human beings in the problem ...
Cao Zijian, Rong Xiaofeng, Du Zhiqiang
doaj   +1 more source

Fault Diagnosis of Oil-Immersed Power Transformer Based on Difference-Mutation Brain Storm Optimized Catboost Model

IEEE Access, 2021
To address the problem of low accuracy of power transformer fault diagnosis, this study proposed a transformer fault diagnosis method based on DBSO-CatBoost model.
Mei Zhang, Wanli Chen, Yu Zhang, Fei Liu, Dongshun Yu, Chaoyin Zhang, Li Gao   +6 more
doaj   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

An MMCW-FCE Method for Evaluating AUV Intelligence on the Algorithm Level

IEEE Access, 2022
Since an intensely subjective expert weights and the divergence of opinions among experts exist in the evaluation, this paper proposes a modified multi-expert combined weight (MMCW)-fuzzy comprehensive evaluation (FCE) method.
Jianhua Cheng, Yanchi Zhao, Jing Cai
doaj   +1 more source