Results 21 to 30 of about 46 (39)

Challenges and Opportunities in Combining Ultrasound and Inductive Coupling for Energy Supply and Bidirectional Data Exchange in Bioelectronics Medicine Implant Networks

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 11, November 2025.
In this contribution, it is shown that miniaturized nerve stimulation implants can be used in collaborative networks. Inductive links and ultrasound are combined to supply these implants with energy and data; the advantages and disadvantages of each method, as well as safety risks and possibilities for improvement are discussed and the best ...
Benedikt Szabo   +5 more
wiley   +1 more source

The impact of EEG preprocessing parameters on ultra‐low‐power seizure detection

open access: yesEpilepsia, Volume 66, Issue 10, Page 3895-3906, October 2025.
Abstract Objective Closed‐loop neurostimulation is a promising treatment for drug‐resistant focal epilepsy. A major challenge is fast and reliable seizure detection via electroencephalography (EEG). Although many approaches have been published, they often lack statistical power and practical utility.
Patrick Reisinger   +8 more
wiley   +1 more source

Fabrication of a Stable, Low‐Cost, Patient‐Specific, Brain Phantom with Ventricles for Ultrasound Imaging

open access: yesAdvanced Engineering Materials, Volume 27, Issue 18, September 2025.
Patient‐specific brain phantoms can replace animal trials, aid presurgical training, and enable in silico disease research on cerebrospinal fluid and ventricles. This study presents a method to create ventricular brain phantoms from three‐dimensional magnetic resonance images brain scans, resulting in durable, tunable, reproducible models that mimic ...
Kajal Chandraprakash Jain   +3 more
wiley   +1 more source

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 21, August 19, 2025.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin   +19 more
wiley   +1 more source

Assessing the Safety Margin for Micromotion‐Induced Strain at Electrode–Tissue Interface: A Finite Element Analysis via COMSOL

open access: yesAdvanced Materials Interfaces, Volume 12, Issue 9, May 5, 2025.
Brain movement significantly impacts the biocompatibility of neural probes due to continuous strain on neural tissue. This study examines strain profiles across various brain models and movement types, challenging the 5% damage threshold at the electrode–tissue interface.
Ali Sharbatian   +3 more
wiley   +1 more source

Assessing the Safety Margin for Micromotion‐Induced Strain at Electrode–Tissue Interface: A Finite Element Analysis via COMSOL (Adv. Mater. Interfaces 9/2025)

open access: yesAdvanced Materials Interfaces, Volume 12, Issue 9, May 5, 2025.
Neural Device Development In article 2401001, Danesh Ashouri Vajari, Thomas Stieglitz, and co‐workers investigate the impact of brain movement on the biocompatibility of neural probes by simulating strain profiles at the electrode‐tissue interface under various displacements.
Ali Sharbatian   +3 more
wiley   +1 more source

Dysregulation of Myelination in Focal Cortical Dysplasia Type II of the Human Frontal Lobe

open access: yesGlia, Volume 73, Issue 5, Page 928-947, May 2025.
Main Points FCD IIa shows a normal radial myelin fiber pattern, thinner myelin sheaths and reduced myelin synthesis. FCD IIb has disorganized myelinated fibers, thicker myelin sheaths, more oligodendrocytes, and an increased transcription rate of myelin genes.
Catharina Donkels   +14 more
wiley   +1 more source

Area Selective Atomic Layer Deposition for the Use on Active Implants: An Overview of Available Process Technology

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 4, February 7, 2025.
Area‐selective atomic layer deposition (ASD) offers wide‐ranging potential for the use on active implants. As the active implants consist of heterogeneous materials, this provides an excellent basis for the application of ASD. In this review, processes for the application on active implants and possible application scenarios are highlighted.
Nicolai Simon   +2 more
wiley   +1 more source

Chronic in vivo sequelae of repetitive acute mfb‐DBS on accumbal dopamine and midbrain neuronal activity

open access: yesJournal of Neurochemistry, Volume 169, Issue 1, January 2025.
The study sheds light on how medial forebrain bundle Deep Brain Stimulation (mfb‐DBS) triggers neural activity and dopamine release in free and behaving animals. Over 8 weeks, 130 Hz mfb‐DBS significantly boosted accumbal dopaminergic activity, increasing phasic and tonic responses.
Lidia Miguel Telega   +4 more
wiley   +1 more source

Process‐Informed Neural Networks: A Hybrid Modelling Approach to Improve Predictive Performance and Inference of Neural Networks in Ecology and Beyond

open access: yesEcology Letters, Volume 27, Issue 11, November 2024.
In this work, we combine process‐based models and neural networks into process‐informed neural networks (PINNs), which incorporate the process knowledge directly into the neural network structure. In a systematic evaluation of spatial and temporal prediction tasks for C‐fluxes in temperate forests, we show the ability of five different types of PINNs ...
Marieke Wesselkamp   +4 more
wiley   +1 more source

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