Results 121 to 130 of about 30,312 (265)

From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Overview of a DNA methylation biomarker development pipeline, from discovery and assay design to screening, performance evaluation, and specificity testing in clinical sample matrices. ABSTRACT Background Tissue‐specific cell‐free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury.
David H. Murray   +6 more
wiley   +1 more source

I Can't Split Myself in Two (or Five): Job Crafting in Highly Demanding and Interdependent Work Environments

open access: yesJournal of Organizational Behavior, EarlyView.
ABSTRACT Employees in highly demanding, interdependent work environments face a dilemma: while avoidance‐focused job crafting can preserve their own well‐being, these self‐initiated changes to their jobs could negatively affect coworkers. Drawing on qualitative interviews with 81 employees concurrently working for multiple agile teams in a European ...
Helene Tenzer   +4 more
wiley   +1 more source

TEST ANALYSIS OF KEY BRAKE PAD PARAMETER ON BRAKE SYSTEM STABILITY

open access: yesJixie qiangdu
To explore the impact of key parameters of brake pads on the dynamics characteristics of the braking system, the test research based on a friction testing machine with a slider-disc structure was conducted.The test research of the impact of key ...
LIN Dongdong   +5 more
doaj  

Physicochemical and Toxicological Characterization of Airborne Brake Wear Particles Reveals Oxidative Stress-Mediated DNA Damage. [PDF]

open access: yesEnviron Sci Technol
Hyman S   +11 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

open access: yesMed Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang   +22 more
wiley   +1 more source

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

open access: yesMovement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori   +9 more
wiley   +1 more source

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