Results 21 to 30 of about 30,312 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Brake fault diagnosis using Clonal Selection Classification Algorithm (CSCA) – A statistical learning approach

Engineering Science and Technology, an International Journal, 2015
In automobile, brake system is an essential part responsible for control of the vehicle. Any failure in the brake system impacts the vehicle's motion. It will generate frequent catastrophic effects on the vehicle cum passenger's safety.
R. Jegadeeshwaran, V. Sugumaran
doaj   +1 more source

Analysis of a Measurement Method and Test System for Pressure Change Rates in Commercial Vehicle Brake Chambers

Sensors, 2022
The pressure change rate (PCR) of the brake chamber is the key control parameter and evaluation index in the pneumatic braking system for intelligent braking.
Gangyan Li, Rui Shen, Yudong Liu, Fan Yang, Jian Hu   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Robust Spot Melting by 3D Spot Arrangements in Electron Beam Powder Bed Fusion

Advanced Engineering Materials, EarlyView.
This work proposes an approach to replace separately melted contours for spot melting in electron beam powder fusion. Adapting the spot arrangements close to the contour combined with stacking yields a comparable surface quality without the inherent challenges of separate contours, as demonstrated, by electron optical images and roughness measurements.
Tobias Kupfer, Lukas Spano, Sebastian Pohl, Carolin Körner, Matthias Markl   +4 more
wiley   +1 more source

Ceramic Particle‐Reinforced Medium‐Entropy Alloys With Outstanding Mechanical Properties Prepared by Novel Micro‐LPBF

Advanced Functional Materials, EarlyView.
An innovative medium entropy alloy (MEA) composite material was fabricated via micro laser powder bed fusion (μ‐LPBF) with appropriate nano‐ceramic particles doping and exhibited markedly improved overall performance, including synergistically enhanced strength and ductility, increased hardness and compressive strength, improved wear resistance and ...
Zhonglin Shen, Mingwang Fu
wiley   +1 more source

Brake Failure Detection and Emergency Braking System

International Journal of Innovative Technology and Exploring Engineering, 2019
Now a days accidents might occur because of varied reasons, the foremost reason is equipment failure and is happened due to improper maintenance of the products. To prevent these abnormal situations and to protect one’s life from these accidents, there's a neccessity for watching of braking system in cars.vehicle safety is a special term means ...
Dhanamjayulu C*, Chalamalasetti Guna Sai, Bharath Srinivas G, Hussain Basha D, Arunkumar G, Venugopal P   +5 more
openaire   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

A Systematic Review of Brake Pad

International Journal of Automotive Science and Technology
The brake system is a mechanism that allows the vehicle to slow down and remain stationary. Most automobiles uses either one or both disk brake and drum brake system.
Mahmut Ünaldı, Ayhan Uyaroğlu
doaj   +1 more source

Strong‐Magnetic Flexible Composites for Magnetically Responsive Soft Robots

Advanced Robotics Research, EarlyView.
This perspective provides an overview of the performance mechanisms, preparation methods, and applications of strong magnetic flexible composite materials in soft actuators (such as gripping, movement, and sensing), and further explores current opportunities and challenges.
Wenwen Li, Shuai Liu, Xinyi Wang, Xinglong Gong, Shouhu Xuan   +4 more
wiley   +1 more source