Results 41 to 50 of about 7,448 (261)
Advanced Science, EarlyView.This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen +7 more
wiley +1 more source
New technical solutions of using rolling stock electrodynamical braking [PDF]
Transport Problems, 2009 The paper considers some theoretical and practical problems associated with the use of traction motor are operating in the generator mode (in braking).
Leonas Povilas LINGAITIS +1 more
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Advanced Science, EarlyView.ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Application of Solenoid Valves for Tram Hydraulic Braking Force Control
Chengshi guidao jiaotong yanjiu［Objective］ The control solenoid valves in the hydraulic braking system of trams mainly include proportional pressure reducing valve and high-speed switching valve. Due to the structural characteristics, the former is poor in pollution resistance and has
ZHANG Yanwei +4 more
doaj +1 more source
Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Design of Electro-mechanical Braking System
Chengshi guidao jiaotong yanjiuObjectiveTo address the issues of significant braking force dispersion, long braking response times, and high braking impact of maglev trains, an application study of EMB (electro-mechanical braking) technology on maglev vehicles is carried out ...
Huijie DU +4 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Increase of Braking Efficiency of Local Electric Trains
Механика машин, механизмов и материалов, 2008 It was developed a braking system for electric trains equipped with cast iron braking shoes, which allows shortening braking distance at emergency braking.
V.I. Senko, Ed.I. Galay , P.K. Rudov
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Long Downhill Braking and Energy Recovery of Pure Electric Commercial Vehicles
World Electric Vehicle JournalThe thermal decay of the brake has a great impact on the long downhill braking stability of pure electric commercial vehicles. Based on the road slope and using the fuzzy control method, the motor regenerative braking force and friction braking force ...
Weisheng Cai, Chengye Liu
doaj +1 more source