Results 81 to 90 of about 90,692 (278)

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Research on Regenerative Braking Combined Control Method for ESP of Pure Electric Vehicles

Chemical Engineering Transactions, 2018
Through the analysis of the regenerative braking system of pure electric vehicles, a series type of regenerative braking control strategy based on a full decoupling braking system is proposed from the perspective of vehicle braking dynamics.
Hongwei Zhang
doaj   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Corrosion Stiction in Automotive Braking Systems. [PDF]

Materials (Basel), 2023
Motta M, Fedrizzi L, Andreatta F.
europepmc   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

fBrake, a Method to Simulate the Brake Efficiency of Laden Light Passenger Vehicles in PTIs While Measuring the Braking Forces of Their Unladen Configurations

Sensors
This study introduces fBrake, a novel simulation method now designed for use in periodic technical inspections of M1 and N1 vehicle categories, addressing challenges posed by Directive 2014/45/EU.
Víctor Romero-Gómez, José Luis San Román   +1 more
doaj   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

Vehicle Brake Wear Particles: Formation Mechanisms, Behavior, and Health Impacts with an Emphasis on Ultrafine Particles

Atmosphere
Brake wear particles (BWPs) represent a major source of non-exhaust particulate matter from road traffic, contributing substantially to human exposure, particularly in urban environments.
Jozef Salva, Miroslav Dado, Janka Szabová, Michal Sečkár, Marián Schwarz, Juraj Poništ, Miroslav Vanek, Anna Ďuricová, Martina Mordáčová   +8 more
doaj   +1 more source

Mathematical modeling as a basis for creation of the effective braking system of hydraulic press ram in upper position

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012
Single-mass mathematical model of hydraulic press ram braking in upper position is considered. The influence of control valve closing time, its constructive characteristics and coefficient of hydraulic system quality on dynamics of ram braking are ...
E. S. Korchak
doaj   +1 more source

The formation of low-mass helium white dwarfs orbiting pulsars: Evolution of low-mass X-ray binaries below the bifurcation period

, 2014
Millisecond pulsars (MSPs) are generally believed to be old neutron stars (NSs) which have been spun up to high rotation rates via accretion of matter from a companion star in a low-mass X-ray binary (LMXB).
Istrate, Alina, Langer, Norbert, Tauris, Thomas   +2 more
core   +1 more source