Results 71 to 80 of about 204,066 (330)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Review on Multi-Objective Mixed-Integer Non-Linear Optimization Programming Methods

Eng
This paper provides a recent overview of the exact, approximate, and hybrid optimization methods that handle Multi-Objective Mixed-Integer Non-Linear Programming (MO-MINLP) problems.
Ahmed Jaber, Rafic Younes, Pascal Lafon, Jihan Khoder   +3 more
doaj   +1 more source

A Branch-and-Bound-Based Algorithm for Nonconvex Multiobjective Optimization

SIAM Journal on Optimization, 2019
A new branch--and--bound-based algorithm for smooth nonconvex multiobjective optimization problems with convex constraints is presented.
Julia Niebling, Gabriele Eichfelder
semanticscholar   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Penerapan Metode Branch and Bound dalam Optimalisasi Produk Mebel (Studi kasus: Toko Mebel di Jalan Marsan, Panam)

Kubik, 2020
Setiap pelaku usaha atau pelaku ekonomi pasti melakukan prinsip ekonomi yaitu dengan usaha atau modal yang sedikit mampu menghasilkan keuntungan yang banyak, sehingga menyebabkan munculnya masalah optimasi.
Elfira Safitri, Sri Basriati, Hasyratul Najmi   +2 more
doaj   +1 more source

Mse-Optimal 1-Bit Precoding for Multiuser Mimo Via Branch and Bound [PDF]

IEEE International Conference on Acoustics, Speech, and Signal Processing, 2018
In this paper, we solve the sum mean-squared error (MSE)-optimal 1-bit quantized precoding problem exactly for small-to-moderate sized multiuser multiple-input multiple-output (MU-MIMO) systems via branch and bound.
Sven Jacobsson, Weiyu Xu, G. Durisi, Christoph Studer   +3 more
semanticscholar   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Parametric branch and bound

Omega, 1978
Abstract The paper describes a procedure for mixed integer programming that allows branches to be imposed ‘by degrees’, which can subsequently be revised or weeded out according to their relative influence. It is an adaptive approach in which the branch and bound tree can be manipulated and restructured. The approach also yields measures of the costs
openaire   +1 more source