Results 101 to 110 of about 14,097 (243)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Rearrangement of DNA fragments: a branch-and-cut algorithm

open access: yesDiscrete Applied Mathematics, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Carlos Eduardo Ferreira   +2 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Branch-and-Cut Algorithms for Colorful Components Problems

open access: yesINFORMS Journal on Computing
We tackle three optimization problems in which a colored graph, where each node is assigned a color, must be partitioned into colorful connected components. A component is defined as colorful if each color appears at most once. The problems differ in the objective function, which determines which partition is the best one.
Claudia Archetti   +2 more
openaire   +2 more sources

Branch-and-Cut Algorithms for Combinatorial Optimization and Their Implementation in ABACUS

open access: yes, 2001
Branch-and-Cut-and-Price algorithms belong to the most successful techniques forsolving mixed integer linear programs and combinatorial optimization problems to optimality (or, at least, with certified quality). In this unit, we concentrate on sequential
Rinaldi, Giovanni   +7 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Research and application of real time video monitoring system based on IoT and 4G wireless VPDN technology

open access: yesDianxin kexue, 2018
For achieving the requirement of real-time video monitoring which is located in the circuit cut-over operating point of the substation of the National Grid Nanjing Branch,China Telecom Nanjing Branch developed a new real-time video monitoring system ...
Zheng DONG, Ying ZHU, Chunze YANG
doaj   +2 more sources

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

open access: yesFEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan   +2 more
wiley   +1 more source

Branch and Cut for Partitioning a Graph into a Cycle of Clusters

open access: yes
In this paper we study formulations and algorithms for the cycle clustering problem, a partitioning problem over the vertex set of a directed graph with nonnegative arc weights that is used to identify cyclic behavior in simulation data generated from nonreversible Markov state models.
Leon Eifler   +2 more
openaire   +3 more sources

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