Results 31 to 40 of about 124,219 (294)

Tactical fixed job scheduling with spread-time constraints [PDF]

, 2014
We address the tactical fixed job scheduling problem with spread-time constraints. In such a problem, there are a fixed number of classes of machines and a fixed number of groups of jobs.
Chen, Bo, Velde, Steef van de, Zhang, Xiandong, Zhou, Shuyu   +3 more
core   +2 more sources

A Branch-and-Price-and-Cut Algorithm for the Integrated Scheduling and Rostering Problem of Bus Drivers

Journal of Advanced Transportation, 2020
In the transportation industry, crew management is typically decomposed into two phases: crew scheduling and crew rostering. Due to the complexity of scheduling and rostering, bus transportation is not an exception and many relevant studies do not ...
Dung-Ying Lin, Chieh-Ju Juan, Ching-Chih Chang   +2 more
doaj   +1 more source

A Branch-and-Price algorithm for railway rolling stock rescheduling [PDF]

Transportation Research Part B: Methodological, 2017
Abstract How to best reschedule their fleet of rolling stock units during a disruption is an optimization problem regularly faced by railway operators. Despite the problem’s high complexity, it is still usually solved manually. In this paper we propose a path based mathematical formulation and solve it using a Branch-and-Price algorithm.
Lusby, Richard Martin, Haahr, Jørgen Thorlund, Larsen, Jesper, Pisinger, David   +3 more
openaire   +2 more sources

The Vehicle Routing Problem with Service Level Constraints

, 2017
We consider a vehicle routing problem which seeks to minimize cost subject to service level constraints on several groups of deliveries. This problem captures some essential challenges faced by a logistics provider which operates transportation services ...
Bulhões, Teobaldo, Hà, Minh Hoàng, Martinelli, Rafael, Vidal, Thibaut   +3 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Short-Term Electricity Price Forecasting via a Reinforcement Learning-Based Dynamic Soft Ensemble Strategy

Energies
To address the high volatility of spot market prices and the feature extraction limitations of single models, a short-term electricity price forecasting method based on a reinforcement learning dynamic soft ensemble strategy is proposed.
Yan Wang, Yongxi Zhao, Kun Liang, Hong Fan   +3 more
doaj   +1 more source

The Edge Set Cost of the Vehicle Routing Problem with Time Windows [PDF]

, 2016
We consider an important generalization of the vehicle routing problem with time windows in which a fixed cost must be paid for accessing a set of edges.
Jepsen, Mads Kehlet, Pisinger, David, Reinhardt, Line Blander   +2 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Increasing security of supply by the use of a local power controller during large system disturbances [PDF]

, 2011
This paper describes intelligent ways in which distributed generation and local loads can be controlled during large system disturbances, using Local Power Controllers.
Bright, C. G., Burt, Graeme, Galloway, S. J., Roscoe, A. J.   +3 more
core   +1 more source