Results 71 to 80 of about 979,870 (292)
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
A Branch-and-Cut algorithm for graph coloring
Discrete Applied Mathematics, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Méndez-Díaz, I., Zabala, P.
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Critical evaluation of branch polarity and apical dominance as dictators of colony astogeny in a branching coral. [PDF]
PLoS ONE, 2009 The high morphological resemblance between branching corals and trees, can lead to comparative studies on pattern formation traits, best exemplified in plants and in some cnidarians.
Lee Shaish, Baruch Rinkevich
doaj +1 more source
Pruning by Isomorphism in Branch-and-Cut
Mathematical Programming, 2001 The paper presents a branch-and-cut for solving (0, 1) integer linear programs having a large symmetry group. The group is used for pruning the enumeration tree and for generating cuts. The cuts are non-standard, cutting integer feasible solutions but leaving the optimal value of the problem unchanged.
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Branch-and-price-and-cut for large-scale multicommodity capacitated fixed-charge network design
EURO Journal on Computational Optimization, 2014 We present a branch-and-price-and-cut algorithm for solving large-scale instances of the multicommodity capacitated fixed-charge network design problem.
Bernard Gendron, Mathieu Larose
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Branch-and-Cut-and-Price for Multi-Agent Pathfinding [PDF]
Proceedings of the Twenty-Eighth International Joint Conference on Artificial Intelligence, 2019 There are currently two broad strategies for optimal Multi-agent Pathfinding (MAPF): (1) search-based methods, which model and solve MAPF directly, and (2) compilation-based solvers, which reduce MAPF to instances of well-known combinatorial problems, and thus, can benefit from advances in solver techniques.
Edward Lam +3 more
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FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source