Results 111 to 120 of about 79,058 (301)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Nicotine information disclosed online by e-cigarette brands popular with young people

Tobacco Prevention and Cessation
Introduction E-cigarette use is most prevalent among adolescents and young adults – and there are often misperceptions about product risk. The purpose of this study was to determine what nicotine information is provided on e-cigarette brand websites ...
Clara Rykaczewski, Alayna P. Tackett, Elizabeth G. Klein, Jill M. Singer, Bo Lu, Loren E. Wold, Dylan D. Wagner, Megan E. Roberts   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Prescription to Over-the-Counter Switch

Voices in Bioethics, 2014
Nearly 55 years after the FDA approved the pill,[i] as it is commonly known, controversies continue to accompany its journey to become an integral part of reproductive choice. Today, a large majority of the countries have access to oral contraceptives as
Marilyn Eshikena
doaj   +1 more source

Triangulating Abuse Liability Assessment for Flavoured Cigar Products Using Physiological, Behavioural Economic and Subjective Assessments: A Within-subjects Clinical Laboratory Protocol [PDF]

, 2018
Introduction In the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted.
Barnes, Andrew J., Bickel, Warren K., Bono, Rose S., Cobb, Caroline O., Eissenberg, Thomas E., Guy, Mignonne C., Hoetger, Cosima, Lester, Rebecca C., Lipato, Thokozeni, Wall, Catherine S.   +9 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Public Policy and Market Competition: How the Master Settlement Agreement Changed the Cigarette Industry [PDF]

This paper investigates the large and unexpected increase in cigarette prices that followed the 1997 Master Settlement Agreement (MSA). We integrate key features of rational addiction theory into a discrete-choice model of the demand for a differentiated
Ciliberto, Federico, Kuminoff, Nicolai
core   +1 more source

A Systematic Review of Online Sex Addiction and Clinical Treatments Using CONSORT Evaluation [PDF]

, 2015
Researchers have suggested that the advances of the Internet over the past two decades have gradually eliminated traditional offline methods of obtaining sexual material.
A Cooper, A Cooper, A Cooper, A Cooper, A Cooper, A Cooper, A Cooper, A Goodman, A Goodman, American Psychological Association, B Paul, C Grov, C Laier, CC Pratt, Centres for Reviews and Dissemination, CH Lou, DG Altman, DJ Stein, DL Delmonico, DL King, HH Jensen, J Orford, J Popay, J Riemersma, J Sadiza, JL Elmore, JN Hook, JP Schneider, JP Schneider, K Daneback, K Shaughnessy, KL Broad, KM Hertlein, KR McBride, L Arai, M Kaufman, M Rodgers, MD Griffiths, MD Griffiths, MD Griffiths, MF Schwartz, MH Orzack, MH Orzack, MH Orzack, MJ McKelland, MP Kafka, MP Twohig, MS Bhatia, NC Raymond, NM Petry, NS Koch, P Carnes, PJ Carnes, PJ Carnes, PW Schnarrs, R Weiss, S Correll, S Eisen, S Sussman, S Turkle, SA Hardy, SC Boies, SC Kalichman, SR Leiblum, TE Mudry   +64 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source