Results 241 to 250 of about 79,058 (301)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The Unregulated Rise of Kratom Drinks: Emerging Challenges and Policy Recommendations. [PDF]

Public Health Rep
Perry T, Chin S.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Adolescents' Exposure to Zero-Alcohol Advertisements and Attitudes and Consumption Intentions Towards Alcohol: A Cross-Sectional Study. [PDF]

Drug Alcohol Rev
Bartram A, Ahad MA, Bogomolova S, Mittinty M, Dono J, Brownbill AL, Harrison NJ, Garcia J, Glavinic I, May M, Bowden J.   +10 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Health response to problematic usage of the internet: A global survey on trends, available treatments and key challenges. [PDF]

J Behav Addict
Khojasteh Zonoozi A, Schofield J, Abolghasemi FS, Achab S, Ambekar A, Bowden-Jones H, Demetrovics Z, Ebrahimi M, Fineberg NA, Khazaal Y, Lee HK, Siste K, Stein DJ, Wu AMS, Zare-Bidoky M, ISAM-GEN Societies' Experts, Potenza MN, Baldacchino AM, Baldacchino AM, Ekhtiari H.   +19 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Psychometric evaluation of a trans-addiction craving questionnaire: The Craving Assessment Scale for Behavioral Addictions and Substance-use Disorders (CASBAS). [PDF]

Addiction
Antons S, Brandtner A, Oelker A, Trotzke P, Wegmann E, Brand M, Müller SM.   +6 more
europepmc   +1 more source

Medicaid prescription cap policies and exemptions for medications for opioid use disorder: A process and content analysis. [PDF]

Health Aff Sch
Hughto JMW, Vento S, Pletta DR, Noh M, Shireman TI, Santostefano CM, Hughes LD, Peterson L, Seymour E, Stettenbauer EG, Dow PM.   +10 more
europepmc   +1 more source