Results 151 to 160 of about 247,073 (223)

A Novel Merocyanine Derivative for Probing Polarity at Cubosome Interfaces

open access: yesAsian Journal of Organic Chemistry, EarlyView.
This study develops a synthetic route to C10SP, a polarity‐sensitive sensor embedded in phytantriol‐based cubosomes. Strategic steps included tertiary amine‐mediated amidation to covalently attach a hydrophobic tail and controlled nitrogen methylation to form the iminium moiety within the indolenine scaffold.
Marcelo J. Eberhardt   +3 more
wiley   +1 more source

Hydrogenation of “Readily Activated Molecule” for Glycine Electrosynthesis

open access: yesAngewandte Chemie, EarlyView.
By recognizing the unique characteristics of the glyoxylate oxime intermediate, we introduce a brand‐new concept of “readily activated molecule”, which empowers Ag as the ideal catalyst for glycine electrosynthesis. Abstract The hydrogenation of glyoxylate oxime is the energy‐intensive step in glycine electrosynthesis. To date, there has been a lack of
Xiaowen Sun   +8 more
wiley   +2 more sources

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu   +11 more
wiley   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

open access: yesAlzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz   +11 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright   +8 more
wiley   +1 more source

Aspectos do realismo-naturalismo no Brasil

open access: diamond, 1953
José Aderaldo Castello
openalex   +2 more sources

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