Results 31 to 40 of about 259,016 (251)
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, 2022 Este artigo objetiva realizar uma análise a respeito do desenvolvimento histórico da didática na educação brasileira, sob a ótica da pedagogia histórico-crítica, ao longo de quatro períodos históricos. Dá centralidade à didática e as relações entre as ideias pedagógicas e o movimento pós-moderno evidenciando suas expressões na didática.
Gonçalves Gobbi, Adalgiza +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Estudios Geologicos, 2013 Se describen dientes aislados de terópodos referidos a Abelisauridae indet. y Carcharodontosauridae cf., procedentes de la Formación Presidente Prudente del Campaniano-Maastrichtiano, en el oeste del estado de San Pablo, Brasil.
M. R. Furtado +2 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Los años iniciales de la intervención bélica holandesa en Brasil, 1621-1635
El Futuro del Pasado, 2013 El trabajo presentado en estas líneas supone un recorrido histórico por los primeros años de actividad militar holandesa en Brasil durante el siglo XVII.
Enrique Garrido Díez De Baldeón
doaj +1 more source
Revista de Estudios Brasileños, 2020 Este artículo presenta un estudio de las estrategias adoptadas por los candidatos a la Presidencia de la República en los debates televisivos durante las elecciones brasileñas de 2018, considerando la relevancia histórica de este objeto de estudio para ...
Fernanda CAVASSANA DE CARVALHO +2 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Revista de Indias, 2016 El presente artículo tiene por objetivo analizar la participación en la Guerra de los Cabanos (1832-1835) de los indígenas provenientes de dos aldeas localizadas en las provincias de Pernambuco y Alagoas.
Mariana Albuquerque Dantas
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source