Results 21 to 30 of about 751 (238)
Educação & Sociedade, 2001 O artigo aborda o tema da Gestão Democrática do Ensino Público no Brasil. Busca identificar como os sistemas de ensino dos estados, do Distrito Federal e dos municípios das capitais organizaram-se para responder ao ordenamento constitucional que ...
Erasto Fortes Mendonça
doaj +1 more source
Lecturas de Economía, 2014 Anomalías de calendario en los mercados accionarios latinoamericanos: una revisión mediante el procedimiento de Bonferroni Resumen: en el presente artículo se corrigen los estudios tradicionales sobre las anomalías de calendario en los principales ...
Emilio Rojas, Werner Kristjanpoller
doaj +1 more source
Educação e Pesquisa, 2008 Neste artigo, analisamos a viagem de Uchoa Cavalcanti (Inspetor de Instrução Pública da Província de Pernambuco) à Corte e às Províncias do Rio de Janeiro e São Paulo em 1879, por meio do relatório oficial dessa viagem, apresentado ao presidente da ...
Alessandra Frota Martinez de Schueler +1 more
doaj +1 more source
Revista Brasileira de Extensão Universitária, 2016 Resumo: A crueldade contra animais coexiste habitualmente com uma vasta gama de outros problemas (violência interpessoal, comportamento anti-social, bullying, etc.) e pode ser identificada em crianças com idade inferior aos sete anos. A violência contra
Daniel Cortes Beretta +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Aldary Toledo : entre arte e arquitetura [PDF]
, 2018 Aldary Henriques Toledo (1915-1998), arquiteto e pintor, dedicou 59 anos de sua vida profissional dividido entre arquiteto e artista. Com 28 anos de idade, participou da mais importante exposição sobre a obras arquitetônicas brasileiras, Brazil Builds ...
Marques, Andre Felipe Rocha
core
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source