Results 41 to 50 of about 1,188,255 (311)
INTEGRAÇÃO CAPITALISTA DO BRASIL CENTRAL
História Revista, 2009 The dominant class of agrarian Central Brazil, supported in financial aid and technical input offered by the authoritarian state would hold the banner of rationalization of production in the field, especially in the livestock industry. Shares of rural unions and associations, tinted with the economic policy of the Government Vargas, would become symbol
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
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Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
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Orchidaceae na região central de São Paulo, Brasil [PDF]
Rodriguésia, 2010 Resumo Este estudo apresenta o levantamento florístico de Orchidaceae ocorrentes em 125 fragmentos florestais de 23 municípios da região central do estado de São Paulo. Foram identificadas 218 espécies distribuídas em 96 gêneros. Os indivíduos coletados em estado vegetativo foram mantidos em casa de vegetação até a ocorrência de floração. A maioria das
Ferreira, Alessandro Wagner Coelho +2 more
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Asymmetric continental deformation during South Atlantic rifting along southern Brazil and Namibia [PDF]
, 2017 Plate restoration of South America and Africa to their pre-breakup position faces the problem of gaps and overlaps between the continents, an issue commonly solved with implementing intra-plate deformation zones within South America.
Koehn, Daniel +2 more
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Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
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CENTRAL DO BRASIL: A IDENTIDADE OUTRA VEZ?
Revista Novos Rumos, 2022 Centrao do Brasil é um filme que reclama, outra vez, a velha reflexão sobre a identidade nacional.
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