Results 31 to 40 of about 42,215 (273)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Translating Robert Schumann : methodology as self-exposure and defense [PDF]

, 2010
This paper is part of a broader research project, which involves the Brazilian Portuguese translation, with notes and commentaries, of the 'Gesammelte Schriften über Musik und Musiker' (On Music and Musicians) by the German composer Robert Schumann (1810-
Azenha Junior, João
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Após a nacionalidade: história do romance e produção romanesca no Brasil e na América Latina

Estudos de Literatura Brasileira Contemporânea, 2011
The essay debates the representation of local identity as a guiding theme of the novel, as well as of critique and literary history in Brazil and Latin-America.
Pedro Dolabela Chagas
doaj  

Os indígenas e o texto teatral no Brasil: um breve itinerário

Das Amazônias
The study of indigenous issues has had a major impact on the Humanities, including the areas of Literary Studies and Performing Arts.Thus, this work highlights the presence of indigenous themes in theatrical texts produced in Brazil over time.Our goal
Dennys Silva-Reis, Wesley Alves Batista
doaj   +1 more source

Digital Literary Reading Experiences by Young Readers

MatLit, 2018
In this article, we present an overview of the results of a survey conducted with Brazilian youngsters aged 15 to 18 years old, belonging to diverse socioeconomic strata. We have identified their means of search and access to the works and the experience
Mônica Araújo, Isabel Frade
doaj   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Emma, Louise and the others, or the bovarism in Portugal and Brazil

Acta Universitatis Lodziensis. Folia Litteraria Polonica, 2018
The author uses the traditional methodology of literary history, making references to the critics of the myth and phantoms and the history of ideas. Based on the ideas of the theorists and writers of the West (George Sand, Charles Baudelaire, Vladimir ...
Anna Kalewska
doaj   +1 more source

Invisible woman: absence of backcountry women in traditional brazilian historiography

Travessias, 2020
This text deals with women’s absence or lack of notoriety in traditional Brazilian historiography. On the other hand, it brings discussions about some important insertions of women in the new historiography, from the seventies forward.
Ivânia Nunes Machado Rocha
doaj   +1 more source

Um brinde às fontes: uma breve história da presença literária em nossas telenovelas = A toast to the sources: a brief history of literary presence in Brazilian soap opera

Scriptorium, 2022
O presente artigo busca estabelecer uma relação entre a teledramaturgia brasileira e suas fontes literárias. Inicialmente, traçamos um breve histórico dessa relação a partir das origens da telenovela no Brasil e suas primeiras produções que consistiam em adaptações dos nossos clássicos.
openaire   +1 more source