Results 31 to 40 of about 71,483 (247)

Decolonizing Brazil through Science Fiction: Bacurau and Brazilian Empowerment

open access: yesHumanities, 2022
The objective of this article is to present an overview of the changes in Brazilian science fiction throughout the past decades, which culminated in the international and national success of the film Bacurau and the emergence of the new subgenres ...
Lidia Zuin
doaj   +1 more source

Identification of Compounds With Antiviral Activity Against SARS-CoV-2 in the MMV Pathogen Box Using a Phenotypic High-Throughput Screening Assay

open access: yesFrontiers in Virology, 2022
Until December 2021, the COVID-19 pandemic has caused more than 5.5 million deaths. Vaccines are being deployed worldwide to mitigate severe disease and death, but continued transmission and the emergence of SARS-CoV-2 variants indicate that specific ...
Laís D. Coimbra   +21 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida   +6 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Pathways to Internationalize Brazilian Journals of Psychology

open access: yesPsicologia: Reflexão e Crítica, 2015
The science of psychology has been developing in the country of Brazil over the last 50 years. Nonetheless, most of the science in this field is published only in Brazilian journals.
Estêvão C. Gamba   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Role of Small-Scale Biofuel Production in Brazil: Lessons for Developing Countries

open access: yesAgriculture, 2017
Small-scale biofuel initiatives to produce sugarcane ethanol are claimed to be a sustainable opportunity for ethanol supply, particularly for regions with price-restricted or no access to modern biofuels, such as communities located far from the large ...
Arielle Muniz Kubota   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

A computational pipeline for image-based statistical analysis of biomolecular condensates dynamics using morphological descriptors

open access: yesScientific Reports
Biomolecular condensation has been extensively studied recently, yet advanced analytical methods for characterizing phase-separated systems remain limited.
Ivan Rosa e Silva   +5 more
doaj   +1 more source

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