Results 71 to 80 of about 727,564 (292)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tear Film Break-up Time in Bipolar Disorder.
Iranian Journal of Psychiatry, 2012 Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms.
Parvin Dibajnia +3 more
doaj +2 more sources
ASCILITE Publications, 2008 Recent years have seen the increasing integration of asynchronous online discussions, often embodying a collaborationist, constructivist pedagogical paradigm, into on- and off-campus postgraduate courses. This paper uses data from published research, a series of course evaluations and one study by the authors into the development of a community of ...
Jo Lander, Sharon Reid
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Anthropometric dividends of Czechoslovakia’s break up [PDF]
, 2014 Processes of transition to democracy and country break up stand out as ideal experiments to estimate the impact of wide institutional reform on well-being.
Costa-Font, Joan, Kossarova, Lucia
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
La pérdida de la democracia en discusión: definiciones para un debate
Confluenze, 2013 The article discusses aspects of the public debate and the controversy of the political groups identified with different positions concerning loss of democracy during the period 1968-1973 in Uruguay.
Gerardo Albistur
doaj +1 more source
The Iowa Review, 1997 At the height of this melodrama she's in, Betsy blanks: What in the hell mean these rosebuds, 11 pink, 1 white? Who in the hell'd send syrup ta suture wounds? Ah, he would, 'course. How wrong. And yet it's not written in her role to tell him. She does not have the heart, yet, that arrives in the cooler via whirlybird, Act IV What mean these sweet ...
openaire +1 more source
Production of hypernuclei in multifragmentation of nuclear spectator matter
, 2007 In peripheral collisions of relativistic heavy ions highly excited spectators containing Lambda-hyperons can be produced. Such strange spectator matter may undergo a break-up into many fragments (multifragmentation) as it is well established for ordinary
A. S. Botvina +2 more
core +1 more source