Results 81 to 90 of about 727,564 (292)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Break-up of Rydberg superatoms via dipole-dipole interactions

, 2013
We investigate resonant dipole-dipole interactions between two "superatoms" of different angular momentum, consisting of two Rydberg-blockaded atom clouds where each of them carries initially a coherently shared single excitation. We demonstrate that the
Eisfeld, Alexander, Genkin, Michael, Möbius, Sebastian, Rost, Jan Michael, Wüster, Sebastian   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Capillary Break-up Rheometry of Low-Viscosity Elastic Fluids

Applied Rheology, 2005
We investigate the dynamics of the capillary thinning and break-up process for low viscosity elastic fluids such as dilute polymer solutions. Standard measurements of the evolution of the midpoint diameter of the necking fluid filament are augmented by ...
Rodd Lucy E., Scott Timothy P., Cooper-White Justin J., McKinley Gareth H.   +3 more
doaj   +1 more source

Do You Still Love Facebook? Understanding Users’ Perceptions Through a Novel Qualitative Method [PDF]

Journal of Emerging Trends in Marketing and Management, 2020
Even though Facebook is the most popular and most used social media platform, it is struggling with increased competition from other platforms, such as Instagram and TikTok, and with a feeling of disconnection from users, coming from problems regarding ...
Alexandra Hutanu, Patricea-Elena Bertea
doaj  

Break up of heavy fermions at an antiferromagnetic instability

, 2010
We present results of high-resolution, low-temperature measurements of the Hall coefficient, thermopower, and specific heat on stoichiometric YbRh2Si2. They support earlier conclusions of an electronic (Kondo-breakdown) quantum critical point concurring ...
Coleman P., Custers J., Custers J., Friedemann S., Friedemann S., Friedemann S., Friedemann S., Friedemann S., Friedemann S., Friedemann S., Gegenwart P., Gegenwart P., Gegenwart P., Gegenwart P., Gegenwart P., Gegenwart P., Goh S. K., Harrison N., Hartmann S., Hertz J. A., Knafo W., Knebel G., Krellner C., Krellner C., Köhler U., Landau L. D., Löhneysen H. v., Mederle S., Millis A. J., Misawa T., Moriya T., Paschen S., Paul I., Paul I., Scheer E., Schröder A., Senthil T., Si Q., Si Q., Si Q., Tokiwa Y., Trovarelli O., Weickert F., Wosnitza J.   +43 more
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Tear Osmolarity, Break-up Time and Schirmer’s Scores in Parkinson’s Disease

Türk Oftalmoloji Dergisi, 2015
Objectives: Dry eye is an important problem in Parkinson’s disease (PD) with a potential to affect life quality. Tear osmolarity, accepted as the gold standard in dry eye diagnosis, has not been studied in this subset of patients so far.
Esin Söğütlü Sarı, Rabia Koç, Alper Yazıcı, Gözde Şahin, Harun Çakmak, Tolga Kocatürk, Sıtkı Samet Ermiş   +6 more
doaj   +1 more source

Anatomy of an Asteroid Break-Up: The Case of P/2013 R3

, 2017
We present an analysis of new and published data on P/2013 R3, the first asteroid detected while disintegrating. Thirteen discrete components are measured in the interval between UT 2013 October 01 and 2014 February 13.
Agarwal, Jessica, Jewitt, Dave, Larson, Stephen, Li, Jing, Mutchler, Max, Weaver, Harold   +5 more
core   +1 more source