Results 111 to 120 of about 127,256 (329)

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin   +19 more
wiley   +1 more source

PERBANDINGAN NILAI BREAKPOINT PADA SISTEM CDMA DAN GSM DI DAERAH URBAN DI SURABAYA [PDF]

open access: yes, 2010
Breakpoint is a decrease in power level without any increase in value of continuous power level. This breakpoint can not be calculated using the formula and can only be determined by looking at graph distance pathloss function. Where there are two pieces
ARIFIN, JOKO JOHAR   +2 more
core  

Breath‐holding and its breakpoint [PDF]

open access: yesExperimental Physiology, 2005
This article reviews the basic properties of breath‐holding in humans and the possible causes of the breath at breakpoint. The simplest objective measure of breath‐holding is its duration, but even this is highly variable. Breath‐holding is a voluntary act, but normal subjects appear unable to breath‐hold to unconsciousness.
openaire   +3 more sources

HEART Camp Connect—Promoting adherence to exercise in adults with heart failure with preserved ejection fraction

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Most adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF). Few adults with HFpEF initiate and sustain long‐term exercise. To promote exercise adherence in adults with HFpEF,
Windy W. Alonso   +10 more
wiley   +1 more source

Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11~13;q11) show recurrent involvement of genes at 20q11.21

open access: yesHaematologica, 2009
The dic(9;20)(p11~13;q11) is a recurrent chromosomal abnormality in patients with acute lymphoblastic leukemia. Although it results in loss of material from 9p and 20q, the molecular targets on both chromosomes have not been fully elucidated.
Qian An   +8 more
doaj   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

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