Results 241 to 250 of about 129,319 (328)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms. [PDF]

open access: yesNucleic Acids Res
Oncins A   +24 more
europepmc   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj   +7 more
wiley   +1 more source

Distinctive molecular features of radiation-induced thyroid cancers. [PDF]

open access: yesSci Adv
Karyadi DM   +18 more
europepmc   +1 more source

Evaluating Creative Output With Generative Artificial Intelligence: Comparing GPT Models and Human Experts in Idea Evaluation

open access: yesCreativity and Innovation Management, EarlyView.
ABSTRACT Traditional techniques for evaluating creative outcomes are typically based on evaluations made by human experts. These methods suffer from challenges such as subjectivity, biases, limited availability, ‘crowding’, and high transaction costs. We propose that large language models (LLMs) can be used to overcome these shortcomings.
Theresa Kranzle, Katelyn Sharratt
wiley   +1 more source

New species-related MIC breakpoints for early detection of development of resistance among Gram-negative bacteria in Swedish intensive care units

open access: bronze, 1999
Håkan Hanberger   +8 more
openalex   +1 more source

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