Results 251 to 260 of about 127,476 (326)

A critical review of management of allogeneic transplant‐eligible adults with Ph+ acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Proposed management of newly diagnosed Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukaemia (ALL) in transplant‐eligible patients. Suggested considerations when deciding the treatment pathway available to a newly diagnosed Ph+ ALL patient that would be deemed transplant eligible. Summary Acute lymphoblastic leukaemia (ALL) in 20%–30% of
Naranie Shanmuganathan, Andrew Grigg
wiley   +1 more source

Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation. [PDF]

Genome Res
Porter VL, Ng M, O'Neill K, MacLennan S, Corbett RD, Culibrk L, Hamadeh Z, Iden M, Schmidt R, Tsaih SW, Nakisige C, Origa M, Orem J, Chang G, Fan J, Nip KM, Akbari V, Chan SK, Hopkins J, Moore RA, Chuah E, Mungall KL, Mungall AJ, Birol I, Jones SJM, Rader JS, Marra MA.   +26 more
europepmc   +1 more source

Genocopy of EVI1‐AML with paraneoplastic diabetes insipidus: PRDM16 overexpression by t(1;2)(p36;p21) and enhancer hijacking

British Journal of Haematology, EarlyView.
Summary Diabetes insipidus (DI) in patients with acute myeloid leukaemia (AML) and chromosome 3q alterations (EVI1/PRDM3/MECOM overexpression) constitutes a poorly understood paraneoplasia. A 44‐year‐old patient presented with clinical and morphological features of this syndrome but, surprisingly, disclosed the rare translocation t(1;2)(p36;p21), with ...
Julian List, Etienne Sollier, Fiona Brown‐Burke, Katherine Kelly, Dietmar Pfeifer, Valeria Shlyakhto, Kristina Maas‐Bauer, Milena Pantic, Christoph Plass, Michael Lübbert   +9 more
wiley   +1 more source

Author Correction: A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript. [PDF]

NPJ Genom Med
Schwartz M, Filser M, Merchadou K, Lemaitre E, Abidallah K, Tenreiro H, Dubois D'enghien C, Rapinat A, Pierre-Noel E, Suybeng V, Espenel M, Baulande S, Adams S, Remenieras A, Renaud C, Aucouturier C, Delnatte C, Garrec C, Renault V, Golmard L, Fourme E, Masliah-Planchon J, Caputo SM.   +22 more
europepmc   +1 more source

Distinct patient, tumour and chimeric antigen receptor T‐cell characteristics are associated with initiating versus sustaining responses to idecabtagene vicleucel in relapsed and refractory multiple myeloma

British Journal of Haematology, EarlyView.
Translational analyses from the KarMMa trial (NCT03361748) highlight that baseline tumour burden, immune environment and chimeric antigen receptor (CAR) T‐cell dynamics influence both the initiation and durability of response to idecabtagene vicleucel (ide‐cel) in relapsed and refractory multiple myeloma.
Nathan Martin, Ethan Thompson, Nicholas Stong, Yang Xu, Olivia Finney, Julie Rytlewski, Erin Flynt, Jessica Marfo, Dante B. Descalzi‐Montoya, Irene Manrique, Bruno Paiva, Nikhil Munshi, Timothy B. Campbell, Shari M. Kaiser   +13 more
wiley   +1 more source

Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors. [PDF]

Nat Commun
Chen F, Zhang Y, Li W, Sedlazeck FJ, Shen L, Creighton CJ.   +5 more
europepmc   +1 more source

Poor prognosis of newly diagnosed multiple myeloma patients with 1p32.3 deletion in single monoallelic deletion and/or in main clone

British Journal of Haematology, EarlyView.
Summary Del(1p32.3) by FISH detection in multiple myeloma (MM) has not been routinely carried out in China. Its clinical significance was not clearly demonstrated. This study analysed clinical characteristics, treatment response and prognostic significance of del(1p32.3).
Hongying You, Weiqin Yao, Lingzhi Yan, Yingying Zhai, Zhi Yan, Jingjing Shang, Shuang Yan, Xiaolan Shi, Song Jin, Xinxin Ge, Hongjie Shen, Jinlan Pan, Depei Wu, Chengcheng Fu   +13 more
wiley   +1 more source

SVseq discloses the genomic complexity of different prenatal, de novo, apparently balanced chromosome rearrangements detected by CMA and karyotype. [PDF]

Ital J Pediatr
Qin S, Wang X, Chen C, Wang J, Zhang Z, Yin Y, Leng X.   +6 more
europepmc   +1 more source

Chronic myeloid leukemia with minor-bcr breakpoint developed hybrid type of blast crisis

, 1998
Tatsuharu Ohno, Shigefusa Hada, Tateo Sugiyama, Takashi Mizumoto, Hiroo Furukawa, Kenichi Nagai   +5 more
openalex   +1 more source