Results 261 to 270 of about 127,256 (329)

Twenty‐Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland

Alimentary Pharmacology &Therapeutics, EarlyView.
Prescribing of first‐line advanced therapy increased from 0 in 2004 to 115 in 2023, and absolute colectomy numbers decreased from 42 in 2004 to 7 in 2023. Piecewise linear regression found a join point in 2013 for both increased advanced therapy prescribing and decreased colectomy rates. ABSTRACT Background The impact of advanced therapy prescribing on
Alexander T. Elford, Nathan Constantine‐Cooke, Phil W. Jenkinson, Beatriz Gros, Nikolas Plevris, Mathew Lyons, Solomon Ong, Neil Greenlees, Victor Velasco‐Pardo, Claire O'Hare, Nicholas T. Ventham, Paul Henderson, David C. Wilson, Shahida Din, Colin L. Noble, Gareth‐Rhys Jones, Ian Arnott, Charlie W. Lees   +17 more
wiley   +1 more source

Chronic myeloid leukemia with minor-bcr breakpoint developed hybrid type of blast crisis

, 1998
Tatsuharu Ohno, Shigefusa Hada, Tateo Sugiyama, Takashi Mizumoto, Hiroo Furukawa, Kenichi Nagai   +5 more
openalex   +1 more source

The Rule of Law and Antifraud Measures in the Allocation of Next Generation Eu Funds

Business Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT This study analyses the different factors that influence the allocation of Next Generation EU (NGEU) Funds among European Union (EU) Member States, particularly on the Recovery and Resilience Facility. We used a sample of the 27 EU countries and applied Fuzzy‐set Qualitative Comparative Analysis (fsQCA) to carry out our analysis.
David Blanco‐Alcántara, Teresa Elvira‐Lorilla, Cristina Sierra‐Calvo   +2 more
wiley   +1 more source

Combining chromosome conformation capture and exome sequencing for simultaneous detection of structural and single-nucleotide variants. [PDF]

Genome Med
Gridina M, Lagunov T, Belokopytova P, Torgunakov N, Nuriddinov M, Nurislamov A, Nazarenko LP, Kashevarova AA, Lopatkina ME, Vasilyev S, Zuev A, Belyaeva EO, Salyukova OA, Cheremnykh AD, Sukhanova NN, Minzhenkova ME, Markova ZG, Demina NA, Stepanchuk Y, Khabarova A, Yan A, Valeev E, Koksharova G, Grigor'eva EV, Kokh N, Lukjanova T, Maximova Y, Musatova E, Shabanova E, Kechin A, Khrapov E, Boyarskih U, Ryzhkova O, Suntsova M, Matrosova A, Karoli M, Manakhov A, Filipenko M, Rogaev E, Shilova NV, Lebedev IN, Fishman V.   +41 more
europepmc   +1 more source

A critical review of management of allogeneic transplant‐eligible adults with Ph+ acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Proposed management of newly diagnosed Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukaemia (ALL) in transplant‐eligible patients. Suggested considerations when deciding the treatment pathway available to a newly diagnosed Ph+ ALL patient that would be deemed transplant eligible. Summary Acute lymphoblastic leukaemia (ALL) in 20%–30% of
Naranie Shanmuganathan, Andrew Grigg
wiley   +1 more source

Comparison of ciprofloxacin and aminoglycoside susceptibility testing for ceftriaxone non-susceptible Enterobacterales by disk diffusion and VITEK 2 vs. broth microdilution using updated Clinical and Laboratory Standards Institute breakpoints. [PDF]

BMC Microbiol
Sohani ZN, Lieu A, Semret M, Cheng MP, Simic N, Bamba R, Patel M, Lawandi A, Lee TC.   +8 more
europepmc   +1 more source

Genocopy of EVI1‐AML with paraneoplastic diabetes insipidus: PRDM16 overexpression by t(1;2)(p36;p21) and enhancer hijacking

British Journal of Haematology, EarlyView.
Summary Diabetes insipidus (DI) in patients with acute myeloid leukaemia (AML) and chromosome 3q alterations (EVI1/PRDM3/MECOM overexpression) constitutes a poorly understood paraneoplasia. A 44‐year‐old patient presented with clinical and morphological features of this syndrome but, surprisingly, disclosed the rare translocation t(1;2)(p36;p21), with ...
Julian List, Etienne Sollier, Fiona Brown‐Burke, Katherine Kelly, Dietmar Pfeifer, Valeria Shlyakhto, Kristina Maas‐Bauer, Milena Pantic, Christoph Plass, Michael Lübbert   +9 more
wiley   +1 more source

Distinct patient, tumour and chimeric antigen receptor T‐cell characteristics are associated with initiating versus sustaining responses to idecabtagene vicleucel in relapsed and refractory multiple myeloma

British Journal of Haematology, EarlyView.
Translational analyses from the KarMMa trial (NCT03361748) highlight that baseline tumour burden, immune environment and chimeric antigen receptor (CAR) T‐cell dynamics influence both the initiation and durability of response to idecabtagene vicleucel (ide‐cel) in relapsed and refractory multiple myeloma.
Nathan Martin, Ethan Thompson, Nicholas Stong, Yang Xu, Olivia Finney, Julie Rytlewski, Erin Flynt, Jessica Marfo, Dante B. Descalzi‐Montoya, Irene Manrique, Bruno Paiva, Nikhil Munshi, Timothy B. Campbell, Shari M. Kaiser   +13 more
wiley   +1 more source

Letter Regarding "Comparison of 2 Assays for Measuring Serum Total Thyroxine Concentration in Dogs and Cats". [PDF]

J Vet Intern Med
Wun MK.
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source