Results 261 to 270 of about 127,476 (326)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Identification of Thermoneutral Zone in Sahiwal Zebu Calves in Subtropical Climate of India. [PDF]

Animals (Basel)
Yadav B, Srivastava A, Yadav P, Swain DK, Anand M, Yadav S, Madan AK.   +6 more
europepmc   +1 more source

Evaluating Creative Output With Generative Artificial Intelligence: Comparing GPT Models and Human Experts in Idea Evaluation

Creativity and Innovation Management, EarlyView.
ABSTRACT Traditional techniques for evaluating creative outcomes are typically based on evaluations made by human experts. These methods suffer from challenges such as subjectivity, biases, limited availability, ‘crowding’, and high transaction costs. We propose that large language models (LLMs) can be used to overcome these shortcomings.
Theresa Kranzle, Katelyn Sharratt
wiley   +1 more source

Progress toward elimination mother-to-child transmission of HBV in Shandong Province, China: Coverage trend in hepatitis B vaccination and HBIG administration, 2017-2024. [PDF]

Hum Vaccin Immunother
Meng X, Zhang W, Yan B, Feng Y, Lu J, Zhang L.   +5 more
europepmc   +1 more source

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers

Cancer Science, EarlyView.
This study discovered actionable novel fusions of RASGRF1 and RASGRF2 in lung adenocarcinoma of never‐smoker and identified that those fusions transformed the cells through phosphorylation of MEK, which was inhibited by cobimetinib treatment. A risk score based on the four‐gene signature could predict the prognosis of surgically resected lung ...
Yuki Terashima, Soohwan Park, Hiroshi Ikeuchi, Takuo Hayashi, Shinya Kojima, Toshihide Ueno, Masachika Ikegami, Rina Kitada, Yoshiyuki Suehara, Shinya Tanaka, Kenji Suzuki, Hiroyuki Mano, Kazuya Takamochi, Shinji Kohsaka   +13 more
wiley   +1 more source

Translocations associated with colour-sidedness are common in northern Swedish cattle breeds. [PDF]

Hereditas
Hinken J, Vanhala T, Gòdia M, Johnsson M, Johansson AM.   +4 more
europepmc   +1 more source

Genetic and Structural Variations in Czech Patients With Congenital Myopathies

Clinical Genetics, EarlyView.
We present 79 unrelated patients with genetically confirmed congenital myopathy (CM). A total of 113 mutant alleles carrying 97 different variants with a presumed pathogenic effect were identified. All but five variants were small scale. The mode of inheritance was autosomal dominant (AD) (44.3%), autosomal recessive (AR) (43.0%), and X‐linked (XL) (12.
Jana Zídková, Barbora Lauerová, Lívie Mensová, Tereza Kramářová, Johana Kopčilová, Kamila Réblová, Magdaléna Soukup Vodičková, Martina Hujňáková, Jana Haberlová, Marie Rohlenová, Radim Mazanec, Jana Šoukalová, Renata Gaillyová, Emílie Vyhnálková, Miroslava Balaščaková, Pavlína Danhofer, Lenka Juříková, Dagmar Grečmalová, Andrea Gřegořová, Pavlína Plevová, Martina Langová, Tomáš Honzík, Martin Magner, Martina Klincová, Pavla Solařová, Mária Šenkeříková, Lenka Fajkusová   +26 more
wiley   +1 more source

On a microdemographic framework for decomposing contemporary fertility dynamics. [PDF]

Sci Rep
Shaw SJ.
europepmc   +1 more source

Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes

Clinical Genetics, EarlyView.
In 132 individuals with limb anomalies, diagnostic yield was 36% (47/132), including 25 novel variants, three cases with new phenotypes, and two candidate loci, HOXA11 and a small 2q31.1 deletion. Mouse data and exome‐wide analysis, key in identifying the candidate loci, represent an important opportunity for gene discovery.
Akram Mokhtari, Jade Charbonneau, Valancy Miranda, Khadijé Jizi, Marie‐Ange Delrue, Patricia Egerszegi, Isabelle Thiffault, Philippe M. Campeau   +7 more
wiley   +1 more source

Healthcare Sector Dynamics in Turkey (2002-2022): Trends, Breakpoints, and Policy Implications (Privatization in the Hospital Sector). [PDF]

Healthcare (Basel)
Ünal E, Yılmaz S.
europepmc   +1 more source