Results 21 to 30 of about 129,319 (328)

Structure of the breakpoint region in CVC of the intrinsic Josephson junctions [PDF]

open access: yes, 2008
A fine structure of the breakpoint region in the current-voltage characteristics of the coupled intrinsic Josephson junctions in the layered superconductors is found.
Mahfouzi, F.   +2 more
core   +2 more sources

A Rat Model of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Shows Attenuated Motivation for Alcohol Self-Administration and Diminished Propensity for Cue-Induced Relapse in Females

open access: yesBiology, 2023
Brain-derived neurotrophic factor (BDNF) has been implicated in alcohol use disorder. The Val66Met polymorphism is a common variant of the BDNF gene (rs6265) which reduces activity-dependent BDNF release, and has been suggested as a risk factor for ...
Emily J. Jaehne   +5 more
doaj   +1 more source

NMDA Receptor Glycine Binding Site Modulators for Prevention and Treatment of Ketamine Use Disorder

open access: yesPharmaceuticals, 2023
Ketamine offers a fast-acting approach to relieving treatment-resistant depression, but its abuse potential is an issue of concern. As ketamine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) ion channel blocker, modulation of NMDAR might be an
Yu-Chin Hsiao   +3 more
doaj   +1 more source

The elusive evidence for chromothripsis. [PDF]

open access: yes, 2014
The chromothripsis hypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'shatter into many pieces' and reassemble into a functioning chromosome.
Bafna, Vineet   +2 more
core   +1 more source

MATCHCLIP: Locate precise breakpoints for copy number variation using CIGAR string by matching soft clipped reads

open access: yesFrontiers in Genetics, 2013
Copy number variations (CNVs) are associated with many complex diseases. Next generation sequencing data enable one to identify precise CNV breakpoints to better under the underlying molecular mechanisms and to design more efficient assays.
Yinghua eWu   +4 more
doaj   +1 more source

A method to identify bimodal weight–length relations: Possible ontogenetic diet and/or metabolism shift effects in Anguilla anguilla (Actinopterygii: Anguilliformes: Anguillidae) [PDF]

open access: yesActa Ichthyologica et Piscatoria, 2018
Background. The power function W = a  · Lb is commonly used to describe the weight–length (W–L) relation (WLR) of fish. Smaller/younger specimens may present different WLR from larger/older ones, introducing errors
M. Lanzoni   +4 more
doaj   +3 more sources

Case report: Identification of a novel triplication of alpha-globin gene by the third-generation sequencing: pedigree analysis and genetic diagnosis

open access: yesHematology, 2023
Background Thalassemia, a common autosomal hereditary blood disorder worldwide, mainly contains α- and β-thalassemia. The α-globin gene triplicates allele is harmless for carriers, but aggravates the phenotype of β-thalassemia.
Yujiao Chen   +5 more
doaj   +1 more source

Extinctions of aculeate pollinators in Britain and the role of large-scale agricultural changes [PDF]

open access: yes, 2014
Pollinators are fundamental to maintaining both biodiversity and agricultural productivity, but habitat destruction, loss of flower resources, and increased use of pesticides are causing declines in their abundance and diversity. Using historical records
Biesmeijer   +8 more
core   +1 more source

Methods for detecting heat stress in hutch-housed dairy calves in a continental climate

open access: yesJournal of Dairy Science, 2023
: Dairy calves exposed to solar radiation, elevated ambient temperature, and humidity are at risk of impaired welfare and productivity. Initial detection of thermal discomfort requires determination of optimal heat stress indicators and thresholds.
B. Dado-Senn   +4 more
doaj   +1 more source

The distribution of cycles in breakpoint graphs of signed permutations [PDF]

open access: yes, 2012
Breakpoint graphs are ubiquitous structures in the field of genome rearrangements. Their cycle decomposition has proved useful in computing and bounding many measures of (dis)similarity between genomes, and studying the distribution of those cycles is ...
Anthony Labarre   +23 more
core   +6 more sources

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