Brain-derived neurotrophic factor (BDNF) has been implicated in alcohol use disorder. The Val66Met polymorphism is a common variant of the BDNF gene (rs6265) which reduces activity-dependent BDNF release, and has been suggested as a risk factor for ...
Emily J. Jaehne+5 more
doaj +1 more source
Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple-color fluorescence in situ hybridization [PDF]
Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line Jl was used for the specific delineation of ...
Anastasi+33 more
core +1 more source
A method to identify bimodal weight–length relations: Possible ontogenetic diet and/or metabolism shift effects in Anguilla anguilla (Actinopterygii: Anguilliformes: Anguillidae) [PDF]
Background. The power function W = a · Lb is commonly used to describe the weight–length (W–L) relation (WLR) of fish. Smaller/younger specimens may present different WLR from larger/older ones, introducing errors
M. Lanzoni+4 more
doaj +3 more sources
NMDA Receptor Glycine Binding Site Modulators for Prevention and Treatment of Ketamine Use Disorder
Ketamine offers a fast-acting approach to relieving treatment-resistant depression, but its abuse potential is an issue of concern. As ketamine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) ion channel blocker, modulation of NMDAR might be an
Yu-Chin Hsiao+3 more
doaj +1 more source
Structure of the breakpoint region in CVC of the intrinsic Josephson junctions [PDF]
A fine structure of the breakpoint region in the current-voltage characteristics of the coupled intrinsic Josephson junctions in the layered superconductors is found.
Mahfouzi, F.+2 more
core +2 more sources
Development of criteria for interpretation and quality assessment of the results of susceptibility testing of Enterobacterales and Pseudomonas aeruginosa to cefepime-sulbactam [PDF]
Objective. To develop criteria for the interpretation and quality assurance of the results of susceptibility testing of Enterobacterales and P. aeruginosa to cefepime-sulbactam. Materials and Methods. The study included 1035 clinical Enterobacterales
Edelstein M.V.+2 more
doaj +1 more source
Kalman Filter Track Fits and Track Breakpoint Analysis [PDF]
We give an overview of track fitting using the Kalman filter method in the NOMAD detector at CERN, and emphasize how the wealth of by-product information can be used to analyze track breakpoints (discontinuities in track parameters caused by scattering ...
Alessandro Cardini+12 more
core +2 more sources
Copy number variations (CNVs) are associated with many complex diseases. Next generation sequencing data enable one to identify precise CNV breakpoints to better under the underlying molecular mechanisms and to design more efficient assays.
Yinghua eWu+4 more
doaj +1 more source
The Catching up Processes of the Regions of the Visegrad Group Countries
The majority of Central and Eastern European post‑socialist countries acceded to the European Union in 2004. The integration of these economies to the Union had begun earlier, which was strengthened by grants from the Structural Funds after the accession.
Imre Lengyel, Balázs Kotosz
doaj +1 more source
Nemonoxacin, a novel nonfluorinated quinolone for the treatment of community-acquired pneumonia. We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets and PK/PD breakpoints of nemonoxacin against Streptococcus pneumoniae using a neutropenic ...
Xin Li+30 more
doaj +1 more source