Results 51 to 60 of about 127,256 (329)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Detecting Spatiotemporal Changes in Vegetation with the BFAST Model in the Qilian Mountain Region during 2000–2017

Remote Sensing, 2019
The Qilian Mountain ecosystems play an irreplaceable role in maintaining ecological security in western China. Vegetation, as an important part of the ecosystem, has undergone considerable changes in recent decades in this area, but few studies have ...
Liying Geng, Tao Che, Xufeng Wang, Haibo Wang   +3 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Cloração de esgoto sanitário: variação de cloro residual e o uso de parâmetros facilmente mensuráveis na indicação de breakpoint [PDF]

Revista DAE, 2017
Neste estudo, foram monitoradas as variações de cloro residual livre e combinado após aplicação de cloro em diferentes dosagens e tempos de contato em esgoto advindo de tratamento preliminar. Em alguns casos, para um mesmo tempo de contato, houve maiores
Raphael Corrêa Medeiros, Luiz Antonio Daniel   +1 more
doaj   +1 more source

Determination of jet fuel thermal deposit rate using a modified JFTOT [PDF]

, 1980
Three fuels having different breakpoint temperatures were studied in the modified jet fuel thermal oxidation tester. The lower stability fuel with a breakpoint of 240 C was first stressed at a constant temperature.
Delfosse, R. J., Nowack, C. J.
core   +1 more source

Study of charge-phase diagrams for coupled system of Josephson junctions

, 2010
Dynamics of stacked intrinsic Josephson junctions (IJJ) in the high-Tc superconductors is theoretically investigated. We calculate the current-voltage characteristics (CVC) of IJJ and study the breakpoint region on the outermost branch of the CVC for the
Hamdipour, M., Shukrinov, Yu. M.
core   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

A Reappraisal of Ventilatory Thresholds in Wheelchair Athletes With a Spinal Cord Injury: Do They Really Exist?

Frontiers in Physiology, 2021
The ventilatory threshold (VT) separates low- from moderate-intensity exercise, the respiratory compensation point (RCP) moderate- from high-intensity exercise. Both concepts assume breakpoints in respiratory data. However, the objective determination of
Julia Kathrin Baumgart, Gertjan Ettema, Katy E. Griggs, Katy E. Griggs, Victoria Louise Goosey-Tolfrey, Christof Andreas Leicht   +5 more
doaj   +1 more source

3D‐Printed Architected Material for the Generation of Foam‐Based Protective Equipment

Advanced Engineering Materials, EarlyView.
This study investigates 3D‐printed architected structures as alternatives to traditional foams in protective gear. It focuses on customizing impact strength and damping through design and manufacturing integration. Testing shows these structures outperform conventional foams, offering enhanced customizability, lower weight, and tunable performance ...
Ali Zolfagharian, Gerard Bel Català, Daniel Saakes, Bernard Rolfe, Ian Gibson, Mehrshad Mehrpouya   +5 more
wiley   +1 more source