Results 71 to 80 of about 127,476 (326)

Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida [PDF]

, 2017
Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Aliabadi, Aliabadi, Blondeau, Brentnall, Brentnall, Cadwell, Dorey, Honeyman, Illambas, Illambas, Jong, Lees, Lees, Lees, Lees, Martinez, Mouton, Mouton, Nielsen, Nielsen, Nightingale, Nouws, Nouws, Nyberg, Papich, Potter, Rey, Sidhu, Sidhu, Toutain, Toutain, Toutain, Toutain, Vilalta, Yoshimura   +34 more
core   +1 more source

Detection of inversion with breakpoints in ARSB causing MPS VI by whole-genome sequencing: lessons learned and best practices

Frontiers in Genetics
IntroductionMucopolysaccharidosis type VI (MPSVI), an autosomal recessive lysosomal storage disorder caused by pathogenic variants in ARSB gene. Usually, whole exome sequencing (WES) can identify these variants, and if WES failed to detect causative ...
Yufeng Huang, Wenyue Deng, Hui Huang, Xiankai Zhang, Xiaohong Chen, Jian Ye, Sukun Luo, Ting Yu, Hui Yao, Hao Du, Xuelian He   +10 more
doaj   +1 more source

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

BMC Medicine, 2022
Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive.
Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying   +6 more
doaj   +1 more source

Cottonseed‐Derived Reusable Bio‐Carbon Gel Ink for DIW Printing Soft Electronic Textiles

Advanced Materials, EarlyView.
A reusable carbon‐gel ink, incorporating cottonseed peptone as a natural mediator, enables cross‐linked ionic polymer networks for advanced conductivity, stability, and biocompatibility. Compatible with direct‐ink‐writing, it facilitates flexible electronics on polymeric and textile substrates for multifunctional applications, including motion sensing,
King Yan Chung, Di Tan, Ziyu He, Xiao Li, Jian Lu, Qingjun Yang, Xinlong Liu, Bingang Xu   +7 more
wiley   +1 more source

Interactive Simplifier Tracing and Debugging in Isabelle [PDF]

, 2014
The Isabelle proof assistant comes equipped with a very powerful tactic for term simplification. While tremendously useful, the results of simplifying a term do not always match the user's expectation: sometimes, the resulting term is not in the form the
D. Aspinall, J.C. Blanchette, L. Sterling, M. Alpuente, M. Ducassé, M. Wenzel, M. Wenzel, T. Nipkow   +7 more
core   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

A Computational Method for the Rate Estimation of Evolutionary Transpositions

, 2015
Genome rearrangements are evolutionary events that shuffle genomic architectures. Most frequent genome rearrangements are reversals, translocations, fusions, and fissions.
J. Ma, J. Ranz, J.H. Nadeau, L. Bulteau, M. Alekseyev, M. Bader, M.A. Alekseyev, P.A. Pevzner, S. Yancopoulos   +8 more
core   +1 more source

Comprehensive analysis of cancer breakpoints reveals signatures of genetic and epigenetic contribution to cancer genome rearrangements.

PLoS Computational Biology, 2021
Understanding mechanisms of cancer breakpoint mutagenesis is a difficult task and predictive models of cancer breakpoint formation have to this time failed to achieve even moderate predictive power.
Kseniia Cheloshkina, Maria Poptsova
doaj   +1 more source

Multi‐Material Gradient Printing Using Meniscus‐enabled Projection Stereolithography (MAPS)

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
MAPS is a new vat‐free printing technique that utilizes programmed delivery of resin droplets with custom formulations to enable multi‐material gradient printing of 3D structures with user‐defined variations in mechanical stiffness, opacity, surface energy, cell densities, and magnetic properties. Abstract Light‐based additive manufacturing methods are
Puskal Kunwar, Arun Poudel, Ujjwal Aryal, Rui Xie, Zachary J. Geffert, Haven Wittmann, Daniel Fougnier, Tsung Hsing Chiang, Mathew M. Maye, Zhen Li, Pranav Soman   +10 more
wiley   +1 more source

Hidden Breakpoints in Genome Alignments [PDF]

, 2012
During the course of evolution, an organism's genome can undergo changes that affect the large-scale structure of the genome. These changes include gene gain, loss, duplication, chromosome fusion, fission, and rearrangement. When gene gain and loss occurs in addition to other types of rearrangement, breakpoints of rearrangement can exist that are only ...
Aaron E. Darling, Knut Reinert, Birte Kehr   +2 more
openaire   +4 more sources