Results 151 to 160 of about 29,256 (309)
Study of Near-Cup Droplet Breakup of an Automotive Electrostatic Rotary Bell (ESRB) Atomizer Using High-Speed Shadowgraph Imaging [PDF]
James T. Wilson +5 more
openalex +1 more source
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Comparative study of the therapeutic effects of different medications on DM-associated dry eye syndrome after vitrectomy. [PDF]
Ge F +5 more
europepmc +1 more source
Effects of Triangular Nozzle Geometry on the Deformation and Breakup of Liquid Jets in Crossflow [PDF]
Yasuhiro Saito +2 more
openalex +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Impact of Time of Day on Dry Eye Disease: Findings from a Large Dry Eye Clinic Cohort. [PDF]
Bair JA +5 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source

