Results 81 to 90 of about 49,970 (240)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Breakup of community social structures in the war-affected northern and eastern provinces in Sri Lanka [PDF]

, 2018
"This paper examines a significant social consequence of the 26 years of conflict in Sri Lanka, namely, the breakup of the community social structures that is visible in the Northern and Eastern Sri Lanka. In our previous research, we revealed this issue
Herath, Dhammika
core   +1 more source

Methods for Predicting Bubble Size Distribution in Turbulent Flow

Water Resources Research
Gas bubbles are commonly observed in both natural and human‐made water systems, and their generation and distribution play pivotal roles in water quality and aquatic habitats.
Pengcheng Li, David Z. Zhu, Hang Wang, Rongcai Tang   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

"Fundamental Physics": Molecular Dynamics vs. Hydrodynamics [PDF]

, 2005
This paper concerns the scale related decoupling of the physics of breaking drops and considers the phenomenon from the point of view of both hydrodynamics and molecular dynamics at the nanolevel.
Batterman, Robert
core  

Numerical simulation investigation of the mechanism of lacquer curtain formation in curtain coating

Engineering Applications of Computational Fluid Mechanics
To study the key factors on integrated curtain formation and breakup in curtain coating production process, we used the numerical simulation method to analyze the various stages of the curtains from full curtain to full thread state by changing the inlet
Jie-min Zhan, Kai Lin, Yi-hua Li, Wen-qing Hu   +3 more
doaj   +1 more source

Experimental Study on the Atomization and Chemiluminescence Characteristics of Ethanol Flame

Journal of Spectroscopy, 2017
The breakup regime in ethanol diffusion flame under different conditions was studied by the high speed camera system combined with the UV camera system. Spray angle and Weber number (We) were used to represent the change of breakup regime.
Qing Zhang, Xudong Song, Qinghua Guo, Yan Gong, Chonghe Hu, Guangsuo Yu   +5 more
doaj   +1 more source