Results 171 to 180 of about 2,128,083 (309)

Use of breast-conserving surgery for treatment of stage I and stage II breast cancer.

, 2009
PURPOSE: To assess the use of breast-conserving surgery in two states reported to differ with respect to surgical treatment of breast cancer. METHODS: A retrospective cohort study based on data collected from medical records and patients was performed ...
Guadagnoli, Edward, Gurwitz, Jerry H., Soumerai, Stephen B., Shapiro, Charles L., Weeks, Jane C., Borbas, Catherine   +5 more
core  

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection. [PDF]

Cancers (Basel)
Rizk M, Mokbel K.
europepmc   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Diagnostic accuracy of intraoperative macroscopic margin evaluation in breast-conserving surgery. [PDF]

Breast
Pop CF, Sanciu-Pop C, Lecomte M, El-Helou E, Moreau M, Dzhamalova G, Verheyden B, Khaled C, Larsimont D, Veys I, Liberale G.   +10 more
europepmc   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Evolution of Physical Intelligence Across Scales

Advanced Intelligent Discovery, EarlyView.
By following the evolution of physical intelligence across scales, this article shows how intelligence arises from materials, structures, physical interactions, and collectives. It establishes physical intelligence as the evolutionary foundation upon which embodied intelligence is built.
Ke Liu, Tianyun Huang, Aming Li, Pengyu Lv, Tingting Qin, Wenhui Chen, Hui Wei, Huiling Duan   +7 more
wiley   +1 more source

Intraoperative measurement of breast-conserving surgery margins: surgical application. [PDF]

Breast Cancer Res
Chen WL, Liu WL, Guo CP, Zhu YY, Ming ZH, Fang YT, Zhang WD, Chen R, Wu JD, Li J, Saunders CM, Zhang YQ.   +11 more
europepmc   +1 more source

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

Animal Models and Experimental Medicine, EarlyView.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang, Yu‐Hua Du, Chuang Song, Lan‐Nv Ma, Lin Luo, De‐Xu Xu, Xiao‐Yan Ma, Zi‐Ying Zhou, Yi Nan, Yi Yang, Ling Yuan   +10 more
wiley   +1 more source

Reoperation rates following breast-conserving surgery in a contemporary cohort. [PDF]

BMC Surg
Lima ADN, Millen EC, Cavalcante FP, Zerwes FP, Mattar A, Antonini M, Kraft MBPL, de Alencar AFO, Queiroz Germano A, Torres DP, Goulart Carneiro E, de Lima CFF, Torresan RZ, Brenelli FP, Lichtenfels M, Bines J, Frasson AL.   +16 more
europepmc   +1 more source