Results 91 to 100 of about 3,052,066 (346)

Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial [PDF]

, 2010
Christiane Kühl, Stefanie Weigel, Simone Schrading, Birke Arand, Heribert Bieling, Roy König, Bernd Tombach, C Leutner, Andrea Rieber-Brambs, D Nordhoff, Walter Heindel, Maximilian Reiser, Hans H. Schild   +12 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Prediction of breast cancer molecular subtypes using radiomics signatures of synthetic mammography from digital breast tomosynthesis [PDF]

, 2020
Jinwoo Son, Si Eun Lee, Eun‐Kyung Kim, Sung‐Won Kim   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intensive Dose-Dense Compared With Conventionally Scheduled Preoperative Chemotherapy for High-Risk Primary Breast Cancer [PDF]

, 2009
Michael Untch, Volker Möbus, Walther Kuhn, B. R. Muck, Christoph Thomssen, Ingo Bauerfeind, Nadia Harbeck, Christoph Werner, Annette Lebeau, Andreas Schneeweiß, S. Kahlert, Franz Koch, Karl Ulrich Petry, D. Wallwiener, R. Kreienberg, Ute‐Susann Albert, Hans‐Joachim Lück, Axel Hinke, F. Jänicke, Gottfried E. Konecny   +19 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Plasma carotenoids and risk of breast cancer over 20 y of follow-up [PDF]

, 2015
A. Heather Eliassen, Xiaomei Liao, Bernard Rosner, Rulla M. Tamimi, Shelley S. Tworoger, Susan E. Hankinson   +5 more
openalex   +1 more source

Breast Cancer [PDF]

The Oncologist, 2001
Abstract Several interesting aspects of breast cancer were covered at this year's American Society of Clinical Oncology meeting. Sentinel lymph node (SN) mapping is now in widespread use, in concert with the general trend toward trying to decrease the morbidity of breast cancer surgery.
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Reconstruções mamárias: estudo retrospectivo de 10 anos

Revista Brasileira de Cirurgia Plástica
INTRODUÇÃO: O câncer de mama é um dos principais problemas de saúde do mundo e sua incidência vem aumentando gradativamente. A mastectomia e as terapias adjuvantes contribuem para o desenvolvimento de complicações físicas e transtornos psicológicos.
Ognev Meireles Cosac, João Pedro Pontes Camara Filho, Ana Paula Galvão de Souza Honorato de Barros, Marina de Souza Borgatto, Bruno Peixoto Esteves, Dhyego Molinari di Castro Curado, Diogo Borges Pedroso, Ricardo Cintra Júnior   +7 more
doaj   +1 more source