Results 111 to 120 of about 28,400 (289)

Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks

open access: yesAdvanced Science, EarlyView.
GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai   +7 more
wiley   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

open access: yesAdvanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado   +10 more
wiley   +1 more source

Breast augmentation should be on the NHS: a discussion of the ethics of rationing [PDF]

open access: green, 2003
Jonathon Pleat   +3 more
openalex   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

open access: yesAdvanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen   +7 more
wiley   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

open access: yesAdvanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan   +19 more
wiley   +1 more source

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics

open access: yesAdvanced Science, EarlyView.
RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu   +19 more
wiley   +1 more source

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