Results 241 to 250 of about 1,403,569 (408)

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

open access: yesAggregate, EarlyView.
The study reveals that optimizing various parameters of sonodynamic therapy (SDT), including the functional characteristics of sonosensitizers and the optimization of acoustic parameters, can significantly enhance SDT therapeutic efficacy. When combined with chemotherapy, this approach effectively overcomes tumor resistance and induces antitumor immune
Zhuoran Gong   +6 more
wiley   +1 more source

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

open access: yesEuropean Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022
Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner   +4 more
wiley   +1 more source

Development and Application of Organic Sonosensitizers in Cancer Therapy

open access: yesAggregate, EarlyView.
This review provides a comprehensive overview of organic sonosensitizers employed in cancer treatment, describing their underlying mechanisms and structure‐activity relationship in terms of sonodynamic therapy. The significance of nanotechnology and combination therapy with other oncological modalities (photothermal therapy, photodynamic therapy, etc.)
Yuhan Ding   +5 more
wiley   +1 more source

Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application

open access: yesAggregate, EarlyView.
This review summarizes recent developments in the design of photothermal charge transfer cocrystals for antibacterial therapy, cancer eradication, and bone regeneration, highlighting the design motivations and chemical principles of the strategies. It offers deep insights into the future development of advanced photothermal cocrystals for targeted ...
Arshad Khan   +8 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

open access: yesAggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail   +5 more
wiley   +1 more source

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity

open access: yesAngewandte Chemie, EarlyView.
This study presents novel macrocyclic peptides with low nanomolar affinity for CD59, an immunomodulatory cell surface receptor associated with human disease. Crystallographic and structure‐activity relationship (SAR) studies reveal peptide CP‐06 mimics the binding of biologically relevant CD59 interaction partners. Dimeric and lipidated CP‐06 analogues
Jasmine K. Bickel   +12 more
wiley   +2 more sources

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