Results 241 to 250 of about 1,436,522 (338)

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

The Surgeon's Digital Eye: Assessing Artificial Intelligence-generated Images in Breast Augmentation and Reduction. [PDF]

Plast Reconstr Surg Glob Open
Yassa A, Akhavan A, Ayad S, Ayad O, Colon A, Ignatiuk A.   +5 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Key Insights From a Decade of Breast Augmentation: Our 5 Critical Decisions in Breast Implant Selection. [PDF]

Plast Reconstr Surg Glob Open
Bletsis PP, van der Lei B.
europepmc   +1 more source

Enhancing Augmentation Mastopexy with Breast Implant by Extended Superior Pedicle Flap [PDF]

Niveen Fathy Al Mahmoudy, Hany Saad, Mohamed Osama   +2 more
openalex   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Breast Augmentation Patient Satisfaction in an Appalachian Region. [PDF]

Cureus
Rahimpour A, Suite S, Dudich M, Denning DA, Bown P, Ray P, Barry R.   +6 more
europepmc   +1 more source

Domain adaptation, self-supervision, and generative augmentation enhance GNNs for breast cancer prediction

Shi Qiu, Yun Zhao, Xiuchang Li
openalex   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Conservative management in a spontaneous pneumoperitoneum post breast augmentation and abdominoplasty: a rare case report. [PDF]

J Surg Case Rep
Alsobyani F, Alshakri K, Attar HM, Abada H, Rokbah HA.   +4 more
europepmc   +1 more source