Results 41 to 50 of about 66,018 (333)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Enhancing Transformer-Based Segmentation for Breast Cancer Diagnosis using Auto-Augmentation and Search Optimisation Techniques [PDF]

open access: yesarXiv, 2023
Breast cancer remains a critical global health challenge, necessitating early and accurate detection for effective treatment. This paper introduces a methodology that combines automated image augmentation selection (RandAugment) with search optimisation strategies (Tree-based Parzen Estimator) to identify optimal values for the number of image ...
arxiv  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

A Comparison of 28 Published Augmentation/Mastopexy Techniques Using Photographic Measurements

open access: yesPlastic and Reconstructive Surgery, Global Open, 2020
Background:. Numerous augmentation/mastopexy methods have been described in the literature, including those reported in 16 publications in 2019. However, objective measurements of breast dimensions are lacking, leaving little information on which to base
Eric Swanson, MD
doaj   +1 more source

Breamy: An augmented reality mHealth prototype for surgical decision-making in breast cancer [PDF]

open access: yesarXiv, 2023
In 2020, according to WHO, breast cancer affected 2.3 million women worldwide, resulting in 685,000 fatalities. By the end of the year, approximately 7.8 million women worldwide had survived their breast cancer making it the most widespread form of cancer globally.
arxiv  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Rupture of 40-year-old silicone gel breast implants: a case report

open access: yesBMC Geriatrics, 2023
Background Implant rupture is one of the complications of breast augmentation surgery. The rupture of silicone implants is often insidious, potentially causing problems at any time.
Hsin-Hsuan Wu   +3 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Photometric Evaluation of Long-term Changes in Breast Shape after Breast Augmentation and Vertical Mammaplasty

open access: yesPlastic and Reconstructive Surgery, Global Open, 2018
Background:. Little information is presently available regarding the long-term effects of breast augmentation and mammaplasties on breast shape. Existing studies typically use 1-dimensional measurements and mean follow-up times seldom exceed 1 year ...
Eric Swanson, MD
doaj   +1 more source

Breast augmentation with silicone implants performed without drainage - retrospective analysis of 726 cases [PDF]

open access: yesVojnosanitetski Pregled, 2017
Introduction: Breast augmentation has been one of the most popular aesthetic procedures. Early complications, like infection, seroma, hematoma and capsular contracture like one of the most frequent long term complication, might be related to ...
Stepić Nenad   +4 more
doaj   +1 more source

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