Results 91 to 100 of about 4,382,279 (297)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Promoting Breast Cancer Awareness and Screening Practices for Early Detection in Low-Resource Settings

European Journal of Breast Health, 2019
Objective:Breast cancer is the most common type of cancer among women in the Philippines. Philippines has one of the highest breast cancer mortality rate and the lowest mortality-to-incidence ratio in Asia.
Tsu-Yin Wu, Joohyun Lee
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preliminary analysis of different organization models of breast cancer screening

Zhongguo aizheng zazhi, 2014
Background and purpose: In recent years, the government of our country attaches importance to the breast cancer screening. This study aimed to provide scientific basis for improving breast cancer screening policy, the results of breast specialized model ...
李毅, 吕艳丽
doaj  

Women’s satisfaction of the Maltese breast screening programme : a cross-sectional survey [PDF]

, 2015
Introduction: Breast cancer is the most common form of cancer among women,1 with 425,000 new cases diagnosed in Europe each year.2 The latter posed a detrimental health problem for years in Malta and consequently, a National Breast Screening ...
Marmarà, Vincent-Anthony, Marmara, Vincent, Curtis, Judi, Marmara, Danika   +3 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer [PDF]

, 2009
Electronic version does not contain associated previously published materialDespite there being pragmatic national guidelines for assigning risk to women with a family history of breast cancer, the evidence base is still sparse.
de Azevedo Moreira Reis, Marta
core   +2 more sources

Breast cancer screening motivation among women: an application of self-determination theory

BMC Primary Care
Background Breast cancer is a major health concern worldwide, especially in Vietnam. This study aimed to explore women’s motivation for and factors related to breast cancer screening.
Chau Thi Dang, Tu Thi Ngoc Nguyen, Trang Thi Thuy Ho, Sunjoo Kang   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Awareness of breast cancer knowledge and its influencing factors among medical staff of maternal and child health hospitals in Ordos city – a cross-sectional survey

Zhongguo gonggong weisheng
ObjectiveTo understand the awareness of breast cancer knowledge and its influencing factors among medical staff in maternal and child health hospitals of all levels in Ordos city.
Ziting CAI, Mengting WANG, Huijiao YAN, Sumeng WANG, Bo ZHANG, Le ZHANG, Zhirong BAI, Youlin QIAO, Chen WANG   +8 more
doaj   +1 more source