Results 51 to 60 of about 4,382,279 (297)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.

, 2007
Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility.
Pharoah, Paul DP, Hogervorst, Frans BL, Dunning, Alison M, Nevanlinna, Heli A, Blomqvist, Carl,, Tommiska, Johanna, Healey, Catherine S, Pharoah, Paul D P, Tollenaar, Rob A E M, Reincke, Scarlett, Peto, Julian, Blomqvist, Carl, Van't Veer, Laura J, Johnson, Nichola, Fletcher, Olivia, Tollenaar, Rob AEM, Broeks, Annegien, Schmidt, Marjanka K, Braaf, Linde M, Hogervorst, Frans B L, Breast Cancer Association Consortium, Easton, Douglas F, Dörk, Thilo   +22 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Breast Cancer Screening [PDF]

North Carolina Medical Journal, 2014
Mammography remains the primary technique for breast cancer screening. Women with dense breast tissue may benefit from digital mammography and tomosynthesis, and women at high risk may benefit from magnetic resonance imaging. However, false-positive results are problematic.
Rita I, Freimanis, Margaret, Yacobozzi
openaire   +2 more sources

Estimating attendance for breast cancer screening in ethnic groups in London. [PDF]

, 2010
BACKGROUND: Breast screening uptake in London is below the Government's target of 70% and we investigate whether ethnicity affects this. Information on the ethnicity for the individual women invited is unavailable, so we use an area-based method similar ...
Jack, Ruth H, Dixon Steve, Jack Ruth H, Dixon, Steve, Elizabeth A Davies, Renshaw, Christine, Jack, Ruth H., Davies, Elizabeth A.; id_orcid, Henrik Møller, Møller Henrik, Renshaw Christine, Møller, Henrik, Steve Dixon, Christine Renshaw, Moller, Henrik; id_orcid, Ruth H Jack, Davies Elizabeth A, Davies, Elizabeth A   +17 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

"If diagnosed early, you will be stressed and die…" drivers for breast cancer screening services uptake among women in Dar es Salaam.

PLOS Global Public Health
Worldwide, there has been an increase in the breast cancer mortality rate, with disproportionately high rates in low and middle-income countries. Addressing breast cancer starts with early detection through screening services.
Nathanael Sirili, Khadija Msami, Thadeus Ruwaichi, Notikela Nyamle   +3 more
doaj   +1 more source

Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view. [PDF]

, 2008
Contains fulltext : 69403.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Mammographic density is known to be a strong risk factor for breast cancer.
Maureen GC Gillan, Astley, Susan M., Ursula M Beetles, Jill Johnson, Griffiths, P.M., Duncan, Karen A., Duffy, S.W., Warwick, J., Griffiths, Miriam A., Jain, Anil K., Geeta Iyengar, Boggis, C.R., Susan M Astley, Pam M Griffiths, Deans, H., Cuzick, J., Roberts, R., Jain, A.K., McGee, Magnus A., Beetles, U., Stephen W Duffy, Nagtegaal, I.D., Deans, Heather, Griffiths, Pam M., Gilbert, F.J., Beetles, U.M., Anil K Jain, Rita Roberts, Roberts, Rita, Gillan, Maureen G. C., Astley, Susan M.; id_orcid, Miriam A Griffiths, Gilbert, Fiona J., Caroline RM Boggis, Gillan, M.G., Cuzick, Jack, Beetles, Ursula M., Jane Warwick, Astley, S.M., Iyengar, G., Iyengar, Geeta, Gillan, Maureen G C, Duffy, Stephen W., Boggis, Caroline R. M., Heather Deans, Karen A Duncan, Fiona J Gilbert, McGee, M.A., Jack Cuzick, Mary Wilson, Duncan, K.A., Iris D Nagtegaal, Magnus A McGee, Johnson, J., Warwick, Jane, Boggis, Caroline R M, Griffiths, M.A., Wilson, M., Nagtegaal, Iris D., Wilson, Mary, Gilbert, F. J. (Fiona J.), Johnson, Jill   +61 more
core   +3 more sources