Results 201 to 210 of about 1,254,223 (252)
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
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Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
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Annals of Surgery, 1948
Cancer of the breast is one of the great diseases with which physicians have struggled since time immemorial. For the modern physician, however, cancer of the breast is a greater challenge than it was to his colleagues of even a generation ago, because today there are improved diagnostic methods that often make it possible to recognize the disease ...
W P, NICOLSON, E D, GRADY
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Cancer of the breast is one of the great diseases with which physicians have struggled since time immemorial. For the modern physician, however, cancer of the breast is a greater challenge than it was to his colleagues of even a generation ago, because today there are improved diagnostic methods that often make it possible to recognize the disease ...
W P, NICOLSON, E D, GRADY
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Surgical Clinics of North America, 1947
THE present communication is the eighth in a series of reports from the Massachusetts General Hospital dealing with the results following operation for carcinoma of the breast.1 2 3 4 5 6 7 There were 382 cases of carcinoma of the breast during the three-year period, 1933–1935, of which 328 were primary cases and 54 had received earlier treatment ...
G W, TAYLOR, R H, WALLACE
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THE present communication is the eighth in a series of reports from the Massachusetts General Hospital dealing with the results following operation for carcinoma of the breast.1 2 3 4 5 6 7 There were 382 cases of carcinoma of the breast during the three-year period, 1933–1935, of which 328 were primary cases and 54 had received earlier treatment ...
G W, TAYLOR, R H, WALLACE
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New England Journal of Medicine, 1960
SINCE the introduction of radical mastectomy by Halsted and Willy Meyer toward the end of the nineteenth century, many surgeons throughout the country have used this particular procedure. The majority of reports attempting to evaluate this technic have been written by authors from large medical centers.
R J, UTZSCHNEIDER, J C, McCANN
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SINCE the introduction of radical mastectomy by Halsted and Willy Meyer toward the end of the nineteenth century, many surgeons throughout the country have used this particular procedure. The majority of reports attempting to evaluate this technic have been written by authors from large medical centers.
R J, UTZSCHNEIDER, J C, McCANN
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Archives of Surgery, 1957
This study is based on an analysis of 787 consecutive cases of cancer of the breast registered in the Tumor Clinic at the University of Illinois Hospitals between the years 1942 and 1955. Of these, only 573 cases are reported on. The remaining 214 represented cases not operated on or those treated elsewhere and referred here in their terminal stages ...
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This study is based on an analysis of 787 consecutive cases of cancer of the breast registered in the Tumor Clinic at the University of Illinois Hospitals between the years 1942 and 1955. Of these, only 573 cases are reported on. The remaining 214 represented cases not operated on or those treated elsewhere and referred here in their terminal stages ...
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The American Journal of Surgery, 1950
Abstract 1. 1. One hundred twelve cases of carcinoma of the breast were reviewed; seventy-five died within five years, twenty-seven lived five years or more without metastasis and ten lived five years or more but had metastasis. 2. 2. Local physical signs were more advanced in the group which died within live years. 3. 3.
C D, SAWYER, E T, LONG, R A, GILMAN
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Abstract 1. 1. One hundred twelve cases of carcinoma of the breast were reviewed; seventy-five died within five years, twenty-seven lived five years or more without metastasis and ten lived five years or more but had metastasis. 2. 2. Local physical signs were more advanced in the group which died within live years. 3. 3.
C D, SAWYER, E T, LONG, R A, GILMAN
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Archives of Surgery, 1967
CARCINOMA of the breast has been the subject of intensive clinical research and philosophical interest for nearly a century. It is the most common primary cancer in women, comprising 22% of all their malignancies, developing in an estimated 6% of women during their lifetime. Approximately 20% of the total mortality from cancer in women is due to cancer
R W, Muir, J W, White
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CARCINOMA of the breast has been the subject of intensive clinical research and philosophical interest for nearly a century. It is the most common primary cancer in women, comprising 22% of all their malignancies, developing in an estimated 6% of women during their lifetime. Approximately 20% of the total mortality from cancer in women is due to cancer
R W, Muir, J W, White
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1984
Separate deposits of carcinoma in the breast and the occurrence of distinctly different histologic types of carcinoma in the same breast have been recognized in 13%–75% of women with breast carcinoma (Cheatle and Cutler 1931; Egan et al. 1969; Egan 1970, 1982; Gallager and Martin 1969; Lagios 1977; Tellem et al. 1962; Morgenstern et al. 1975). Criteria
R L, Egan, M B, McSweeney
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Separate deposits of carcinoma in the breast and the occurrence of distinctly different histologic types of carcinoma in the same breast have been recognized in 13%–75% of women with breast carcinoma (Cheatle and Cutler 1931; Egan et al. 1969; Egan 1970, 1982; Gallager and Martin 1969; Lagios 1977; Tellem et al. 1962; Morgenstern et al. 1975). Criteria
R L, Egan, M B, McSweeney
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