Results 71 to 80 of about 1,254,223 (252)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Therapeutic targeting of Integrin v 6 in breast cancer [PDF]

, 2014
BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast ...
Thomas, GJ, Louise Jones, J., Eccles, D, Hart, I. R. (Ian R.), Kendrew, Jane, Chou, Patrick, Gillett, C., Jordan, L, Violette, S., Brentnall, A., Duffy, S.W., Warwick, J., Thomas, Gareth J., Saha, A, Hart, I.R., Bowen, R, Barry, S.T., Green, Andrew R, Gillett, Cheryl, Vallath, S, Bowen, R., Haider, Syed, Barry, Simon T, Moore, K.M., Hart, Ian R., Barry, Simon T., Gabe, R., Haider, S., Chelala, C, Jones, J.L., Thomas, Gareth J, Chelala, C., Eccles, Diana, Ellis, Ian O, Kendrew, J., Green, Andrew R., Weinreb, PH, Jones, JL, Chou, P, Vallath, S., Marshall, John F., Jordan, L., Brouilette, Kellie, Kendrew, J, Duffy, Stephen W, Ellis, I.O., Quinlan, P., Quinlan, P, Gabe, R, Haider, S, Moore, Kate M, Jordan, Lee, Hart, Ian R, Marshall, J.F., Brentnall, Adam, Moore, KM, Jones, J. Louise, Barry, ST, Gillett, C, Warwick, J, Thompson, Alastair M, Weinreb, Paul H, Vallath, Sabari, Chou, P., Green, AR, Thompson, A.M., Thompson, AM, Saha, Antonio, Violette, Sheila, Tapper, W.J., Hart, IR, Ellis, IO, Jones, J Louise, Tapper, William J., Brentnall, A, Weinreb, P.H., Brouilette, K., Tapper, Will, Gabe, Rhian, Thompson, Alastair M., Saha, A., Eccles, D., Violette, Shelia, Tapper, William J, Marshall, JF, Thomas, G J., Weinreb, Paul H., Duffy, Stephen W., Moore, Kate M., Brouilette, K, Green, A.R., Quinlan, Phillip, Duffy, SW, Ellis, Ian, Warwick, Jane, Marshall, John F, Bowen, Rebecca, Chelala, Claude, Tapper, WJ, Violette, S, Ellis, Ian O.   +100 more
core   +1 more source

Primary neuroendocrine carcinoma of the breast: report of 2 cases and literature review

Radiology Case Reports, 2017
Neuroendocrine tumors of the breast are very rare accounting for less than 0.1% of all breast cancers and less than 1% of all neuroendocrine tumors.
Fernando Collado-Mesa, MD, Jose M. Net, MD, Geetika A. Klevos, MD, Monica M. Yepes, MD   +3 more
doaj   +1 more source

Radioresistance in carcinoma of the breast

The Breast, 2004
Radiotherapy plays an important role in the management of breast cancer. Whilst its role in achieving local control following surgery in patients with early stage cancer is well established, there is still unclear evidence to explain the factors governing radioresistance in patients who develop recurrences both in the breast and axilla.
J K A, Jameel, V S R, Rao, L, Cawkwell, P J, Drew   +3 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Identification and validation of novel amplification target genes in human breast cancer [PDF]

, 2007
Gene amplification is a major mechanism for overexpression of potential oncogenes in cancer. Several amplifications have already been described in breast cancer.
Ruiz, Christian
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The role of 18F-FDG PET/CT in detecting rare post-surgical cardiac metastasis of metaplastic breast carcinoma: a case report

Frontiers in Oncology
Metaplastic carcinoma of the breast is an extremely rare and highly aggressive malignancy associated with a poor prognosis. Breast spindle cell carcinoma is a subtype of metaplastic carcinoma.
Taiping Liao, Guoxu Fu, Lingxiao Li, Qinlin Qi, Li Li, Yongjun Long   +5 more
doaj   +1 more source

Myoepithelial Carcinoma of the Breast

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013
Breast carcinoma is the commonest cancer among females in a majority of the Indian cities. The advances in the research and management have improved the breast cancer survival significantly in the past three decades globally. Adenocarcinoma is the commonest histological variant which arises from the ductal epithelia.
Santhosh R, Kemba Padu, Bipin Singh TH, M Birkumar Sharma, Th. Sudhir Chandra Singh   +4 more
openaire   +3 more sources