Results 41 to 50 of about 2,027 (134)
Advanced Healthcare Materials, Volume 13, Issue 31, December 16, 2024.The Multi‐Layer Spheroid (MLS) formation method can construct Fibrosis‐Encapsulated Tumoroids (FETs), which replicate the structural characteristics of peritumoral fibrosis, serving as a tissue‐level simulator for cancer research and drug evaluation in solid tumors.
Yeonsue Jang +5 more
wiley +1 more source
Overexpression of malic enzyme is involved in breast cancer growth and is correlated with poor prognosis [PDF]
J Cell Mol MedAbstract Malic enzyme (ME) genes are key functional metabolic enzymes playing a crucial role in carcinogenesis. However, the detailed effects of ME gene expression on breast cancer progression remain unclear. Here, our results revealed ME1 expression was significantly upregulated in breast cancer, especially in patients with oestrogen receptor ...
Hu W +5 more
europepmc +2 more sources
Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer [PDF]
, 2009 Introduction: Inhibitor of apoptosis (IAPs) proteins are a family of proteins that can block apoptosis in normal cells and have been suggested to cause resistance to apoptosis in cancer.
Foster, Fiona M. +6 more
core +1 more source
Targeted Cancer Therapy‐on‐A‐Chip
Advanced Healthcare Materials, Volume 13, Issue 29, November 22, 2024.Targeted cancer therapy (TCT) minimizes side effects by specifically treating tumor cells. Traditionally tested with 2D cell cultures and animal studies, TCT now utilizes cancer‐on‐a‐chip (CoC) platforms for in vitro testing. This review examines CoCs in developing and testing TCTs, identifying biomarkers, and evaluating both free and encapsulated TCTs,
Heba Abed +7 more
wiley +1 more source
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. [PDF]
, 2019 Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors.
Aran, D +9 more
core +1 more source
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448 [PDF]
, 2016 Relative expression of KDM5B, MALAT1, SNAIL, Vimentin and miR 448 normalized against GAPDH in MCF10A WT, MCF10A OE, MDA-MB-231 WT and MDA-MB-231 KD cells. Data are representative of 3 independent experiments and analyzed by student’s t-test. All data are
Alexander Wu +7 more
core +3 more sources
Molecular Oncology, Volume 18, Issue 10, Page 2569-2585, October 2024.This study reveals CHPF's role in breast cancer cell survival under nutrient deprivation, proposing a model where TGF‐β and CHPF increase cell surface SDC1, promoting macropinocytosis in cancer cells. The chondroitin sulfate‐specific binding peptide, C6S‐p, shows promise in counteracting CHPF effects by binding to CS‐SDC1, leading to SDC1 degradation ...
Hung‐Rong Yen +9 more
wiley +1 more source
Latent transforming growth factor binding protein 4 (LTBP4) is downregulated in mouse and human DCIS and mammary carcinomas [PDF]
, 2011 BACKGROUND: Transforming growth factor beta (TGF-beta) is able to inhibit the proliferation of epithelial cells and is involved in the carcinogenesis of mammary tumors.
Kretschmer, C. +3 more
core +2 more sources