Results 61 to 70 of about 2,575,116 (250)

Training Program for Girls with Hearing Disability about Breast Self- Examination in Assiut City [PDF]

Egyptian Journal of Health Care
Background: Girls with hearing disability continue to undervalue the practice of breast self-examination, despite Egypt's ever-expanding programs to raise breast cancer awareness.
Shaimaa M. Goda, Shimaa Elwardany Aly, Aya M. Abd El Hafez, Shaimaa A. Khalaf   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is down-regulated in metaplastic breast cancer [PDF]

, 2017
Purpose We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells.
Singh, P, Yague, E, Raguz, S, Ali, S, Lin, ML, Coombes, RC, Asaduzzaman, M, Hu, Y, Gallon, J, Shousha, S, Haoxiang, M, Lam, EWF, Constantinou, S   +12 more
core   +1 more source

Knowledge, Attitude and Practices of Breast Self Examination (BSE) in Women of Karachi

Journal of the Dow University of Health Sciences, 2011
Objective: To assess the knowledge, attitude and practices ofbreast self examination (BSE) in women attending gynecological units of major public sector hospitals ofKarachi. Study Design: Cross sectional survey.
Rabail Raza, Masood Hussain Rao, Sadia Raza   +2 more
doaj   +4 more sources

Construction of a novel mitochondrial oxidative stress-related genes prognostic system and molecular subtype characterization for breast cancer

Discover Oncology
Purpose Breast cancer (BRCA) is the most common malignant tumor among women, characterized by high incidence rates and mortality rates. Oxidative stress and immunity, particularly in relation to mitochondria, have emerged as pivotal factors in breast ...
Ying Liu, Yang Li, Yanzheng Zhu, Min Wang, Zheyao Luan   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

DETERMINAN PEMERIKSAAN PAYUDARA SENDIRI SEBULAN SEKALI SECARA TERATUR PADA WANITA USIA SUBUR DI DESA KUBUTAMBAHAN

Jurnal Ilmu Keperawatan Maternitas, 2020
Significant condition occurred in increased rate of breast cancer, based on global statistical data. Awareness of breast cancer prevention methods is very important in reducing morbidity and mortality caused by breast cancer. One of them with breast self-
Desak Ketut Sugiartini, Ari Pertama Watiningsih   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

French college of gynecologists and obstetricians (CNGOF) recommendations for clinical practice: Place of breast self-examination in screening strategies

Breast
Breast cancer is the most common female cancer in the world. Numerous studies have shown that the risk of metastatic disease increases with tumor volume.
Vincent Lavoue, Amélia Favier, Sophie FRANCK, Gérard Boutet, Anne-Sophie Azuar, Susie Brousse, François Golfier, Catherine Uzan, Charlotte Vaysse, Sébastien Molière, Martine Boisserie-Lacroix, Edith Kermarrec, Jean-Yves Seror, Yann Delpech, Élisabeth Luporsi, Christine M. Maugard, Nicolas Taris, Nathalie Chabbert-Buffet, Jonathan Sabah, Khalid Alghamdi, Xavier Fritel, Carole Mathelin   +21 more
doaj   +1 more source

Improving early detection of breast cancer in sub-Saharan Africa: why mammography may not be the way forward

Globalization and Health, 2019
Background and methods The prevention and control of breast cancer in sub-Saharan Africa (SSA) is an increasingly critical public health issue. Breast cancer is the most frequent female cancer in SSA and mortality rates from this disease are the highest ...
Eleanor Black, Robyn Richmond
doaj   +1 more source