Results 111 to 120 of about 2,612,746 (337)

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

open access: yesAdvanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu   +13 more
wiley   +1 more source

Breast Feeding and Co-morbidities on Mothers and Infants in Two Main Hospitals of Diyala Province, Baquba, Iraq

open access: yesDiyala Journal of Medicine, 2019
Background: Breast milk is the only food fully adapted to the physiology of human infants. Optimal breastfeeding is defined as initiating breastfeeding immediately after birth exclusively breastfeeding until 6 months of infant age, and continuing ...
Kareem Assi Obaid
doaj   +2 more sources

COMPLICATIONS OF INTRAUTERINE DEVICE (I.U.D) AND ITS’ IMPACTS ON BREAST FEEDING PERIOD AT THE TIME OF PLACEMENT

open access: yesنشریه پرستاری ایران, 2002
Background: Placing I.U.D is a very effective method in the prevention of pregnancy, which has increasingly became popular. Women have found it an effective, safe and comfortable method all over the world.
Ghorbani, S   +3 more
doaj  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

KNOWLEDGE OF LACTATING MOTHERS ABOUT IMPORTANCE AND NECESSITY OF BREAST FEEDING IN INFANTS - ISFAHAN PROVINCE

open access: yesJournal of Research in Medical Sciences, 2000
Introduction. In spite of high physiologic ability of lactation in mothers, most of them have not cooperation for breast feeding. Mothers' knowledge and attitude are important for lactation behavior.
M HASHEMIPOOR   +8 more
doaj  

Breast feeding, obesity, and asthma association: clinical and molecular views. [PDF]

open access: yesClin Mol Allergy, 2023
Kian N   +7 more
europepmc   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

open access: yesAdvanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou   +14 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

open access: yesAdvanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang   +16 more
wiley   +1 more source

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