Results 311 to 320 of about 298,071 (357)

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source

Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense

ChemBioChem, EarlyView.
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell Cox, Frank Surup   +13 more
wiley   +1 more source

Plastic recycling: Challenges and opportunities

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This review offers an in‐depth exploration of current strategies for recycling plastic waste, focusing on mechanical, chemical, and energy recovery methods. It situates these strategies within the context of modern practices by examining ongoing research methodologies and specific case studies related to various types of plastic waste.
Pradeep Sambyal, Parisa Najmi, Devansh Sharma, Ehsan Khoshbakhti, Hadi Hosseini, Abbas S. Milani, Mohammad Arjmand   +6 more
wiley   +1 more source

Exclusive breast-feeding - a pipe dream? [PDF]

, 2003
Bland, R.M., Coovadia, H.M., Goga, A.E., Rollins, N.C.   +3 more
core  

Enzymatic Synthesis of Functional PEGylated Adipate Copolymers

ChemPlusChem, EarlyView.
This study explores a one‐pot, one‐step enzymatic polycondensation process to create amphiphilic PEG‐adipate variants with improved physicochemical properties that can self‐assemble into nanoparticles. By varying hydrophobic and functionalised diols, the impact on nanoparticle formation, stability, and drug encapsulation is examined.
Eleni Axioti, Emily G. Dixon, Thomas Jepras, Fen Tin He, Peter J. V. Hartman, Bradley Hopkins, Vincenzo Di Bari, Jiraphong Suksiriworapong, Valentina Cuzzucoli Crucitti, Luciano Galantini, Iolanda Francolini, Robert J Cavanagh, Vincenzo Taresco   +12 more
wiley   +1 more source

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source