Results 321 to 330 of about 72,727 (364)

DeepCCDS: Interpretable Deep Learning Framework for Predicting Cancer Cell Drug Sensitivity through Characterizing Cancer Driver Signals

Advanced Science, EarlyView.
DeepCCDS leverages prior knowledge and self‐supervised learning to model cancer driver signals for drug sensitivity prediction. It captures complex regulatory patterns enabling more biologically informed representations. The framework outperforms existing methods across datasets, offering improved accuracy and interpretability.
Jiashuo Wu, Jiyin Lai, Xilong Zhao, Ziyi Wang, Yongbao Zhang, Liqiang Wang, Yinchun Su, Yalan He, Siyuan Li, Ying Jiang, Junwei Han   +10 more
wiley   +1 more source

Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening

Advanced Science, EarlyView.
A label‐free organoid photoacoustic imaging (LFOPI) system is developed for precise volumetric drug screening evaluation. As a proof of concept, LFOPI's performance in chemotherapy and immunotherapy drug screening assays are further evaluated. The LFOPI offers unique non‐invasive, label‐free capabilities for tumor organoids, and contributes to the ...
Xiaofei Luo, Maike Chen, Han Shan, Xize Yu, Qibo Lin, Qian Tao, Xiongwei Wei, Changling Lv, Ziyan Chen, Fan Zhuo, Xi Zhu, Jiaxing He, Zhaoxi Li, Chunlong Fei, Jing Xu, Juan Su, Zeyu Chen, Shuang Zhao, Xiang Chen   +18 more
wiley   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Evaluating the Quality of Online Patient Information for Prepectoral Breast Reconstruction Using Polyurethane-Coated Breast Implants. [PDF]

JPRAS Open
Bruno E, Borea G, Valeriani R, De Luca A, Lo Torto F, Loreti A, Ribuffo D.   +6 more
europepmc   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Breast implant rupture.

JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR), 2003
Spinhoven, M., de Schepper, Arthur
openaire   +2 more sources