Results 171 to 180 of about 7,036,024 (258)

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Receptor‐Triggered Peptide Self‐Assembly Enables Multivalent Recruitment of Endogenous Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
Receptor‐triggered supramolecular self‐assembly converts monovalent antibody‐recruiting molecules into multivalent platforms directly on cancer cell membranes. The resulting fibrillar assemblies present clustered haptens that efficiently recruit endogenous antibodies, enabling selective complement‐mediated immune killing of EGFR‐positive cancer cells ...
Yihui Wang, Xia Wu, Chenguang Zhao, Hong Han, Wensha Xie, Dan Yuan, Junfeng Shi   +6 more
wiley   +1 more source

Human Milk Sodium Monitoring Across the Continuum of Lactation: From Secretory Activation to Established Lactation. [PDF]

Nutrients
Mizuno K, Himi T.
europepmc   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Exclusively Pumping Women's Milk Production and Pumping and Feeding Dynamics-An Online Survey. [PDF]

Healthcare (Basel)
Gridneva Z, McEachran JL, Ireland DJ, Perrella SL, Geddes DT.   +4 more
europepmc   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Virucidal Efficacy of Holder Pasteurization of Breast Milk in a Portable Device. [PDF]

Pathogens
Suchkov MI, Yakovchuk EV, Shustova EY, Sirazova DI, Zolotareva AD, Karpova EV, Aksenova EL, Sotskova SE, Kozlovskaya LI.   +8 more
europepmc   +1 more source

Model-Informed Evaluation of Hydroxyurea Exposure During Lactation. [PDF]

Clin Pharmacol Ther
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Hosawi A, Irie K, Dong M, Ware J, Ware R, Mizuno T.   +5 more
europepmc   +2 more sources

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

The maternal gut-fetal brain axis: role of maternal microbial metabolome in early neurodevelopment. [PDF]

Front Nutr
Scoglio MJ, Samala T, Ghalat NJ, Jayaraman A, Pettersson S.   +4 more
europepmc   +1 more source