Results 181 to 190 of about 472,303 (213)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

T-cell lymphoma of the breast and ovary presenting as a second malignant neoplasm in a pediatric leukemia survivor: A case report and literature review. [PDF]

Rare Tumors
Alvarez-Palacios O, Ojeda-Campos L, Rodríguez A, Díaz-Juarez GE, Figueroa-Torres JM, Juárez-Velázquez R, Juárez-Figueroa U, Gallardo-Navarro JJ, Segundo-Galvez LF, Ocampo-Bárcenas A.   +9 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Clinical and radiological features of primary breast sarcoma: a 14-year retrospective case series from a single institution. [PDF]

Int J Surg Case Rep
Patanawanitkul R, Ariyadej V, Suvannarerg V, Thiravit S, Muangsomboon K, Korpraphong P.   +5 more
europepmc   +1 more source

Successful treatment of a large-sized triple-negative breast cancer: A case report. [PDF]

Medicine (Baltimore)
Zeng D, Liu X, Fu S, Liu Z, Zhao X, Zhong L, Wang X.   +6 more
europepmc   +1 more source

Terminology binding with SNOMED CT to bridge differences in information structures: a feasibility study. [PDF]

J Biomed Semantics
Rossander A, Wetterbro D, Karlsson D.
europepmc   +1 more source