Results 41 to 50 of about 294,551 (284)

Neoplasm of uncertain behaviour of the breast—a retrospective study in a breast unit [PDF]

ecancermedicalscience, 2018
Breast lesions include a heterogeneous group of entities with variable clinical behaviour and morphological presentation, mostly classified as benign or malignant, with predictable behaviour. However, there are lesions with clinical, breast imaging and/or biopsy characteristics that do not clarify their nature. These lesions have an uncertain behaviour
Jorge Simões, Matilde Gonçalves, Pedro Santos Ferreira, Xavier de Sousa, Luís Cortez, Manuel Vitor Rigueira, Luís C. Branco   +6 more
openaire   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Papillary neoplasm of the breast – A review and update

Human Pathology Reports, 2021
Papillary neoplasms of the breast encompass a broad spectrum of lesions that remain one of the most challenging topics in breast pathology. Although recognizing the papillary architecture is straightforward, classification into in situ and invasive can be problematic due to the overlapping features among these lesions. This review focuses on diagnosing
Yihong Wang, Elizabeth C. Song
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Determining the date of diagnosis – is it a simple matter? The impact of different approaches to dating diagnosis on estimates of delayed care for ovarian cancer in UK primary care [PDF]

, 2009
Background Studies of cancer incidence and early management will increasingly draw on routine electronic patient records. However, data may be incomplete or inaccurate.
A Majeed, A Rosemary Tate, A Verdecchia, AB Ryerson, Alexander GR Martin, B Rachet, B Yawn, BA Goff, BA Goff, BA Goff, CR Bankhead, F Berrino, Jackie A Cassell, JMJ Kirwan, K Sikora, M Richards, ML Wynn, MP Coleman, R Horton, R Jones, R Lawrenson, Sarah R Anderson, SW Pascoe, Tarita Murray-Thomas, VL Allgar, VL Allgar, W Hamilton, W Hamilton   +27 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Can the application of computed tomography laser mammography (CTLM) in dense breast (category 3,4 according to ACR) examinations combined with x-ray mammography enhance the detection of breast cancer? [PDF]

, 2009
Background: The aim of this study was an attempt to answer the question whether laser mammography in dense breast (classified as category 3,4 according to ACR) examination together with x-ray mammography can enhance the detection of breast cancer ...
Adamiak, Dagmara, Bobek-Billewicz, Barbara, Gorczewski, Kamil, Sczasny, Monika, Stasiak-Preis, Gabriela, Steinhof-Radwańska, Katarzyna, Stobiecka, Ewa   +6 more
core  

Acupuncture for cancer pain in adults. [PDF]

, 2011
BACKGROUND: Forty percent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief.
Akhileswaran, Alimi, Alimi, Aung, Bardia, Beuken-van Everdingen, Beuken-van Everdingen, Brainin-Mattos, Carr, Cata, Chen, Chen, Coleman, Dang, Dang, Dang, Davis, Derry, Dillon, Ernst, Ernst, Ezzo, Filshie, Filshie, Filshie, Furlan, Goudas, Gralow, Green, Guo, He, Higgins, Hopwood, Jadad, Johnson, Keskinbora, Kwon, Laird, Lee, Lipton, Lund, Lundeberg, Lundeberg, MacPherson, Manheimer, Manheimer, Mao-Ying, Mao-Ying, Mehling, Meng, Minton, Nguyen, Payne, Petrut, Poulain, Qaseem, Ripamonti, Rosier, Sima, Strong, Sun, Trinh, Twycross, Urch, Vallerand, White, White, White, Xia, Yu, Zhang   +70 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. [PDF]

, 2017
Background: This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods: A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124,
Chlebowski, Rowan, Clayton, Sheilah, Sarkissyan, Marianna, Vadgama, Jaydutt V, Wu, Yanyuan   +4 more
core   +2 more sources