Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Performed a Qualitative and Quantitative of Breast Self-Examination: a Checklist Approach
Journal of Community Health Research, 2013 Introduction: Breast neoplasia is the most common cancer among women in both developed and developing countries. Over 1.15 million women in the world detecting with breast neoplasia each year and the mortality rate is 502,000 cases from this cancer.
Mahshid Bokaie, Mohammad Hassan Lotfi
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Human medicines European public assessment report (EPAR): Zirabev, bevacizumab, Colorectal Neoplasms,Breast Neoplasms,Carcinoma, Non-Small-Cell Lung,Carcinoma, Renal Cell,Uterine Cervical Neoplasms, Date of authorisation: 14/02/2019, Revision: 1, Status: Authorised [PDF]
, 2019 openalex +1 more source
Metaplastic Breast Cancer: A Case Report on a Rare Neoplasm of the Breast
CureusMetaplastic breast cancer represents a very rare and histopathologically diverse subtype of breast cancer. It shows neoplastic epithelial differentiation into squamous cells and/or mesenchymal-like components, resulting in its aggressive behavior and poor prognosis compared to other types of breast cancer.
Akanchha Kujur, Shipha +4 more
openaire +2 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Scientometric analysis of lipid metabolism in breast neoplasm: 2012–2021 [PDF]
, 2023 Xiaobing Lin +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
BILATERAL BREAST METASTASIS FROM AN ADENOCARCINOMA OF LUNG: A CASE REPORT
National Journal of Medical Research, 2011 Breast metastases from extramammary neoplasms are very rare. Breast metastasis is often confused with primary breast malignancy. Accurate differentiation of metastatic breast carcinoma from primary breast carcinoma is of crucial importance because the ...
Jitendra G Nasit +2 more
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Malignant phyllodes tumor with extensive lipomatous differentiation
Radiology Case Reports, 2020 Phyllodes tumors are uncommon neoplasms of the breast. Lipomatous differentiation of malignant phyllodes tumor is a rare stromal alteration of this fibroepithelial tumor, demonstrated as a fat-containing mass on imaging.
Jeffrey Landy, MD +6 more
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