Results 81 to 90 of about 657,592 (265)

Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features. [PDF]

Pathol Oncol Res, 2021
Turkevi-Nagy S, Báthori Á, Böcz J, Krenács L, Cserni G, Kővári B.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

BREAST TUMOR (PAPILLOMA) IN A PREGNANT WOMAN (CLINICAL CASE)

Мать и дитя в Кузбассе
The weakly positive Rh factor (Du phenotype) was described by The cause of neoplasms is the human papillomavirus (HPV), which infects about 80% of the world's population.
Светлана Ивановна Елгина, Екатерина Владимировна Грищенко, Елена Владимировна Рудаева, Кира Борисовна Мозес, Наталья Степановна Черных   +4 more
doaj  

Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology. [PDF]

Int J Endocrinol, 2021
Panagiotou G, Triantafyllidou S, Tarlatzis BC, Papakonstantinou E.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase‐20 in human cancers

Cancer Medicine, 2019
Background Matrix metalloproteinases‐20 (MMP20) expression is widely regarded as tooth specific, with expression limited to dental hard tissues. Recently, we reported MMP20 expression and interaction with dentin sialophosphoprotein (DSPP), a member of ...
Jaya Aseervatham, Saxena Geetu, Charles C. Anunobi, Komal Koli, Kalu U. E. Ogbureke   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Lesões impalpáveis da mama marcadas com suspensão de carvão: avaliação de aspectos anatomopatológicos, viabilidade de interpretação e resposta inflamatória

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Analisar a eficácia da suspensão de carvão inerte na marcação de lesões impalpáveis mamárias e as alterações morfológicas associadas ao seu uso, além de determinar se há ou não prejuízo na interpretação destas lesões pelo patologista.
Teresa Cristina Santos Cavalcanti, Osvaldo Malafaia, Paulo Afonso Nunes Nassif, Thelma Larocca Skare, Daniel Cury Ogata, Marcelo Tizzot Miguel, Larissa Krüger Gomes   +6 more
doaj   +1 more source